Academic Journal
Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment
| العنوان: | Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment |
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| المؤلفون: | Wang, Wenyu, Han, Youngjin, Jo, Hyun A, Lee, Juwon, Song, Yong Sang |
| المساهمون: | 한영진, 조현아, 이주원, 송용상 |
| بيانات النشر: | BMC |
| سنة النشر: | 2020 |
| المجموعة: | Seoul National University: S-Space |
| مصطلحات موضوعية: | Exosomes, Hypoxia, Tumor microenvironment, MiRNA, LncRNA, Non-coding RNA |
| الوصف: | Exosomes are small extracellular vesicles secreted by almost all the cells. Molecular cargos of exosomes can partially reflect the characteristics of originating cells. Exosome-mediated cell-to-cell interactions in the microenvironment are critical in cancer progression. Hypoxia, a key pro-cancerous feature of the tumor microenvironment, alters the releasing and contents of exosomes. A growing body of evidence shows that hypoxia induces more aggressive phenotypes in cancer. Of note, non-coding RNAs shuttled in hypoxic tumor-derived exosomes have been demonstrated as fundamental molecules in regulating cancer biology and remodeling tumor microenvironment. Furthermore, these hypoxic tumor-derived exosomal non-coding RNAs can be detected in the body fluids, serving as promising diagnostic and prognostic biomarkers. The current review discusses changes in cancer behaviors regulated by exosomes-secreted non-coding RNAs under hypoxic conditions. ; This work was supported by the grant from Samsung Research Funding Center of Samsung Electronics (project number: SPFC-MA1501-51). WW is a recipient of China Scholarship Council scholarship (CSC number: 201908260030). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1756-8722 |
| Relation: | Journal of Hematology & Oncology. 2020 Jun 05;13(1):67; http://hdl.handle.net/10371/168611 |
| DOI: | 10.1186/s13045-020-00893-3 |
| الاتاحة: | http://hdl.handle.net/10371/168611 https://doi.org/10.1186/s13045-020-00893-3 |
| Rights: | The Author(s) |
| رقم الانضمام: | edsbas.69EC28DF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17568722 |
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| DOI: | 10.1186/s13045-020-00893-3 |