Academic Journal
Total synthesis of (+)-pentamethylsalvianolic acid C
| العنوان: | Total synthesis of (+)-pentamethylsalvianolic acid C |
|---|---|
| المؤلفون: | Ben Alford, Helmut Hugel |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Medicinal and biomolecular chemistry not elsewhere classified, Organic chemistry not elsewhere classified, Not Assigned |
| الوصف: | The total synthesis of a methylated analogue of (+)-Salvianolic acid C has been achieved. Key aspects of the synthetic route include an economical Cu(I) acetylide coupling, unique carboxyl activation conditions via microwave irradiation and a novel lipase catalysed kinetic resolution of a racemic mixture of secondary alcohol Danshensu. The preparation of this methylated analogue will not only improve the bioavailability, but also enable access to new and wider bioactivity applications for (+)-Salvianolic acid C. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | 10779/rmit.27455304.v1 |
| الاتاحة: | https://figshare.com/articles/journal_contribution/Total_synthesis_of_-pentamethylsalvianolic_acid_C/27455304 |
| Rights: | All rights reserved |
| رقم الانضمام: | edsbas.69E23F58 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |