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Concentration versus time plots for simulated steady-state drug concentrations.
| العنوان: | Concentration versus time plots for simulated steady-state drug concentrations. |
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| المؤلفون: | Lufina Tsirizani Galileya, Roeland E. Wasmann, Chishala Chabala, Helena Rabie, Janice Lee, Irene Njahira Mukui, Anneke Hesseling, Heather Zar, Rob Aarnoutse, Anna Turkova, Diana Gibb, Mark F. Cotton, Helen McIlleron, Paolo Denti |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Medicine, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, Virology, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, optimize tuberculosis dosing, identifying factors altering, human immunodeficiency virus, 1 %, drug &# 8211, suboptimal drug exposures, used nonlinear mixed, pediatric pharmacokinetic studies, line tuberculosis drugs, large pharmacokinetic studies, hiv per se, gov registration numbers, 0 %, around 3 months, age also affected, lower rifampicin exposures, pharmacokinetic results |
| Time: | 78, 61 |
| الوصف: | *When taken at the same time . Simulations of children weighing 14 kg on first-line tuberculosis drugs with or without antiretrovirals. Plot A shows the rifampicin concentrations achieved by a child on lopinavir/ritonavir versus when they are not on lopinavir/ritonavir. Plot B shows the isoniazid concentrations achieved by a child on lopinavir/ritonavir taken at the same time with isoniazid or on efavirenz, versus when they are not on any antiretrovirals. Plot C shows the pyrazinamide concentrations achieved by a child on lopinavir/ritonavir versus when they are not on lopinavir/ritonavir. The grey dashed lines represent the lower and upper boundaries of the maximum concentrations (C max ) range reported in adults. The children were dosed according to 2010 WHO-recommended pediatric tuberculosis doses. Figures D, E, F, and G in S1 Text show VPCs stratified by study and lopinavir/ritonavir. VPC, visual predictive check; WHO, World Health Organization. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/figure/Concentration_versus_time_plots_for_simulated_steady-state_drug_concentrations_/24601550 |
| DOI: | 10.1371/journal.pmed.1004303.g003 |
| الاتاحة: | https://doi.org/10.1371/journal.pmed.1004303.g003 https://figshare.com/articles/figure/Concentration_versus_time_plots_for_simulated_steady-state_drug_concentrations_/24601550 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.69D33722 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pmed.1004303.g003 |
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