Academic Journal
Delivery of therapeutic carbon monoxide by gas-entrapping materials
| العنوان: | Delivery of therapeutic carbon monoxide by gas-entrapping materials |
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| المؤلفون: | Byrne, James D., Gallo, David, Boyce, Hannah, Becker, Sarah L., Kezar, Kristi M., Cotoia, Alicia T., Feig, Vivian R., Lopes, Aaron, Csizmadia, Eva, Longhi, Maria Serena, Lee, Jung Seung, Kim, Hyunjoon, Wentworth, Adam J., Shankar, Sidharth, Lee, Ghee Rye, Bi, Jianling, Witt, Emily, Ishida, Keiko, Hayward, Alison, Kuosmanen, Johannes L. P., Jenkins, Josh, Wainer, Jacob, Aragon, Aya, Wong, Kaitlyn, Steiger, Christoph, Jeck, William R., Bosch, Dustin E., Coleman, Mitchell C., Spitz, Douglas R., Tift, Michael, Langer, Robert, Otterbein, Leo E., Traverso, Giovanni |
| المصدر: | Science Translational Medicine ; volume 14, issue 651 ; ISSN 1946-6234 1946-6242 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS) |
| سنة النشر: | 2022 |
| الوصف: | Carbon monoxide (CO) has long been considered a toxic gas but is now a recognized bioactive gasotransmitter with potent immunomodulatory effects. Although inhaled CO is currently under investigation for use in patients with lung disease, this mode of administration can present clinical challenges. The capacity to deliver CO directly and safely to the gastrointestinal (GI) tract could transform the management of diseases affecting the GI mucosa such as inflammatory bowel disease or radiation injury. To address this unmet need, inspired by molecular gastronomy techniques, we have developed a family of gas-entrapping materials (GEMs) for delivery of CO to the GI tract. We show highly tunable and potent delivery of CO, achieving clinically relevant CO concentrations in vivo in rodent and swine models. To support the potential range of applications of foam GEMs, we evaluated the system in three distinct disease models. We show that a GEM containing CO dose-dependently reduced acetaminophen-induced hepatocellular injury, dampened colitis-associated inflammation and oxidative tissue injury, and mitigated radiation-induced gut epithelial damage in rodents. Collectively, foam GEMs have potential paradigm-shifting implications for the safe therapeutic use of CO across a range of indications. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1126/scitranslmed.abl4135 |
| الاتاحة: | http://dx.doi.org/10.1126/scitranslmed.abl4135 https://www.science.org/doi/pdf/10.1126/scitranslmed.abl4135 |
| رقم الانضمام: | edsbas.69D25D9E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/scitranslmed.abl4135 |
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