Academic Journal
Relationship between Urinary AD7c‐NTP with Cerebral Microbleeds Based on APOE Genotype
| العنوان: | Relationship between Urinary AD7c‐NTP with Cerebral Microbleeds Based on APOE Genotype |
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| المؤلفون: | Yong-peng Yu, Zheng, Ya-li |
| المساهمون: | Demarin, Vida, National Natural Science Foundation of China |
| المصدر: | BioMed Research International ; volume 2021, issue 1 ; ISSN 2314-6133 2314-6141 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Objective . This study was performed to investigate the association between urinary Alzheimer‐associated neuronal thread protein (AD7c‐NTP) with cerebral microbleeds (CMBs) based on the apolipoprotein E ( APOE ) genotypes. Methods . A total of 471 patients with acute cerebral infarction screened by magnetic sensitive imaging were enrolled in this study. Among them, twenty‐seven cases of mixed CMBs were excluded. A total of 444 patients were divided into two groups according to the presence or absence of CMBs: CMBs group ( n = 92) and noncerebral microbleeds group (nCMBs) ( n = 352). Urine AD7c‐NTP levels were measured using a human enzyme immunoassay kit. Results . In patients with lobar CMBs, there was an interaction between urine AD7c‐NTP levels and APOE genotypes ( p = 0.01). In patients with APOE ε3/ε3 allele, the odds ratio of lobar CMBs per standard deviation of urinary AD7c‐NTP levels was 0.92 (95% CI: 0.70‐1.19). In patients with APOE ε2+ or ε4+ allele, the multivariate‐corrected odds ratio of lobar CMBs per standard deviation of urinary AD7c‐NTP levels was 2.95 (95% CI: 1.38‐6.27). Conclusion . A higher level of urinary AD7c‐NTP is involved in lobar CMBs, not deep CMBs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1155/2021/3928060 |
| الاتاحة: | https://doi.org/10.1155/2021/3928060 http://downloads.hindawi.com/journals/bmri/2021/3928060.pdf http://downloads.hindawi.com/journals/bmri/2021/3928060.xml https://onlinelibrary.wiley.com/doi/pdf/10.1155/2021/3928060 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.69C010F5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2021/3928060 |
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