Academic Journal
Efficient Synthesis and Antibacterial Profile of Bis(2-hydroxynaphthalene- 1,4-dione)
| العنوان: | Efficient Synthesis and Antibacterial Profile of Bis(2-hydroxynaphthalene- 1,4-dione) |
|---|---|
| المؤلفون: | Novais, Juliana S., Rosandiski, Aline C., de Carvalho, Carolina M., de Saules Silva, Letícia S., dos S. Velasco de Souza, Lais C., Santana, Marcos V., Martins, Nathalia R.C., Castro, Helena C., Ferreira, Vitor F., Gonzaga, Daniel T.G., de Resende, Gabriel O., de C. da Silva, Fernando |
| المساهمون: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil |
| المصدر: | Current Topics in Medicinal Chemistry ; volume 20, issue 2, page 121-131 ; ISSN 1568-0266 |
| بيانات النشر: | Bentham Science Publishers Ltd. |
| سنة النشر: | 2020 |
| الوصف: | Background: Antibacterial resistance is a serious public health problem infecting millions in the global population. Currently, there are few antimicrobials on the market against resistant bacterial infections. Therefore, there is an urgent need for new therapeutic options against these strains. Objective: In this study, we synthesized and evaluated ten Bis(2-hydroxynaphthalene-1,4-dione) against Gram-positive strains, including a hospital Methicillin-resistant (MRSA), and Gram-negative strains. Method: The compounds were prepared by condensation of aldehydes and lawsone in the presence of different L-aminoacids as catalysts in very good yields. The compounds were submitted to antibacterial analysis through disk diffusion and Minimal Inhibitory Concentration (MIC) assays. Result: L-aminoacids have been shown to be efficient catalysts in the preparation of Bis(2- hydroxynaphthalene-1,4-dione) from 2-hydroxy-1,4-naphthoquinones and arylaldehydes in excellent yields of up to 96%. The evaluation of the antibacterial profile against Gram-positive strains (Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, S. epidermidis ATCC 12228) also including a hospital Methicillin-resistant S. aureus (MRSA) and Gram-negative strains (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Klebsiella pneumoniae ATCC 4352), revealed that seven compounds showed antibacterial activity within the Clinical and Laboratory Standards Institute (CLSI) levels mainly against P. aeruginosa ATCC 27853 (MIC 8-128 µg/mL) and MRSA (MIC 32-128 µg/mL). In addition, the in vitro toxicity showed all derivatives with no hemolytic effects on healthy human erythrocytes. Furthermore, the derivatives showed satisfactory theoretical absorption, distribution, metabolism, excretion, toxicity (ADMET) parameters, and a similar profile to antibiotics currently in use. Finally, the in silico evaluation pointed to a structure-activity relationship related to lipophilicity for these compounds. This feature may help them in acting ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.2174/1568026619666191210160342 |
| الاتاحة: | http://dx.doi.org/10.2174/1568026619666191210160342 http://eurekaselect.com/article/download/177328 |
| رقم الانضمام: | edsbas.69B8C461 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/1568026619666191210160342 |
|---|