Academic Journal
Changes in Free-Living Glycemic Profiles after 12 Months of Lifestyle Intervention in Children with Overweight and with Obesity
| العنوان: | Changes in Free-Living Glycemic Profiles after 12 Months of Lifestyle Intervention in Children with Overweight and with Obesity |
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| المؤلفون: | Karnebeek, Kylie, Rijks, Jesse M., Dorenbos, Elke, Gerver, Willem-Jan M., Plat, Jogchum, Vreugdenhil, Anita C. E. |
| المصدر: | Karnebeek , K , Rijks , J M , Dorenbos , E , Gerver , W-J M , Plat , J & Vreugdenhil , A C E 2020 , ' Changes in Free-Living Glycemic Profiles after 12 Months of Lifestyle Intervention in Children with Overweight and with Obesity ' , Nutrients , vol. 12 , no. 5 , 1228 . https://doi.org/10.3390/nu12051228 |
| سنة النشر: | 2020 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | childhood obesity, glucose metabolism, lifestyle intervention, continuous glucose measurement, CARDIOVASCULAR RISK-FACTORS, INSULIN-RESISTANCE, OXIDATIVE STRESS, PLASMA-GLUCOSE, TYPE-2, HEART, ONSET, HYPERGLYCEMIA, ADIPOSITY, EXERCISE |
| الوصف: | Previous studies demonstrated that hyperglycemic glucose concentrations are observed in children that are overweight or have obesity. The aim of this study was to evaluate the effect of a 12 month lifestyle intervention on free-living glycemic profiles in children that were overweight or had obesity, and the association of the alterations with changes in cardiovascular risk parameters. BMI z-score, free-living glycemic profiles, continuous overlapping net glycemic action (CONGA), and cardiovascular parameters were evaluated before and after a multidisciplinary lifestyle intervention, in 33 non-diabetic children that were overweight or had obesity. In children with a decrease in BMI z-score, the duration which glucose concentrations were above the high-normal threshold (6.7 mmol/L) and the glycemic variability decreased significantly. In these children, a decrease in median sensor glucose was associated with decreases in LDL-cholesterol, and systolic and diastolic blood pressure z-score. A decrease in BMI z-score was associated with a decrease in CONGA1, 2, and 4. In conclusion, the glycemic profiles in free-living conditions in children that were overweight improved in children with a decrease in BMI z-score after lifestyle intervention. In those children, changes in median sensor glucose concentrations were associated with changes in LDL-cholesterol and blood pressure z-scores. These results suggest that glucose homeostasis can improve after one year of lifestyle intervention and that these improvements are associated with improvements in cardiovascular health parameters. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.3390/nu12051228 |
| الاتاحة: | https://cris.maastrichtuniversity.nl/en/publications/fcd1bf84-2e9a-4c67-8a3d-980880751206 https://doi.org/10.3390/nu12051228 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.69732EFB |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/nu12051228 |
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