Academic Journal
Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients
| العنوان: | Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients |
|---|---|
| المؤلفون: | Zhao, Xiang-Na, You, Yue, Cui, Xiao-Ming, Gao, Hui-Xia, Wang, Guo-Lin, Zhang, Sheng-Bo, Yao, Lin, Duan, Li-Jun, Zhu, Ka-Li, Wang, Yu-Ling, Li, Li, Lu, Jian-Hua, Wang, Hai-Bin, Fan, Jing-Fang, Zheng, Huan-Wei, Dai, Er-Hei, Tian, Lu-Yi, Ma, Mai-Juan |
| المساهمون: | Natural Science Foundation of Beijing Municipality, National Natural Science Foundation of China, Emergency Science and Technology Project for Prevention and Control of COVID-19 |
| المصدر: | Signal Transduction and Targeted Therapy ; volume 6, issue 1 ; ISSN 2059-3635 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| الوصف: | While some individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present mild-to-severe disease, many SARS-CoV-2-infected individuals are asymptomatic. We sought to identify the distinction of immune response between asymptomatic and moderate patients. We performed single-cell transcriptome and T-cell/B-cell receptor (TCR/BCR) sequencing in 37 longitudinal collected peripheral blood mononuclear cell samples from asymptomatic, moderate, and severe patients with healthy controls. Asymptomatic patients displayed increased CD56 bri CD16 − natural killer (NK) cells and upregulation of interferon-gamma in effector CD4 + and CD8 + T cells and NK cells. They showed more robust TCR clonal expansion, especially in effector CD4 + T cells, but lack strong BCR clonal expansion compared to moderate patients. Moreover, asymptomatic patients have lower interferon-stimulated genes (ISGs) expression in general but large interpatient variability, whereas moderate patients showed various magnitude and temporal dynamics of the ISGs expression across multiple cell populations but lower than a patient with severe disease. Our data provide evidence of different immune signatures to SARS-CoV-2 in asymptomatic infections. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41392-021-00753-7 |
| الاتاحة: | http://dx.doi.org/10.1038/s41392-021-00753-7 https://www.nature.com/articles/s41392-021-00753-7.pdf https://www.nature.com/articles/s41392-021-00753-7 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.691C4570 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41392-021-00753-7 |
|---|