Academic Journal
Diagnostic accuracy of research criteria for prodromal frontotemporal dementia
| العنوان: | Diagnostic accuracy of research criteria for prodromal frontotemporal dementia |
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| المؤلفون: | Benussi, Alberto, Premi, Enrico, Grassi, Mario, Alberici, Antonella, Cantoni, Valentina, Gazzina, Stefano, Archetti, Silvana, Gasparotti, Roberto, Fumagalli, Giorgio G., Bouzigues, Arabella, Russell, Lucy L., Samra, Kiran, Cash, David M., Bocchetta, Martina, Todd, Emily G., Convery, Rhian S., Swift, Imogen, Sogorb-Esteve, Aitana, Heller, Carolin, van Swieten, John C., Jiskoot, Lize C., Seelaar, Harro, Sanchez-Valle, Raquel, Moreno, Fermin, Laforce, Robert Jr, Graff, Caroline, Synofzik, Matthis, Galimberti, Daniela, Rowe, James B., Masellis, Mario, Tartaglia, Maria Carmela, Finger, Elizabeth, Vandenberghe, Rik, Mendonça, Alexandre, Tiraboschi, Pietro, Butler, Chris R., Santana, Isabel, Gerhard, Alexander, Le Ber, Isabelle, Pasquier, Florence, Ducharme, Simon, Levin, Johannes, Sorbi, Sandro, Otto, Markus, Padovani, Alessandro, Rohrer, Jonathan D., Borroni, Barbara |
| المصدر: | Benussi , A , Premi , E , Grassi , M , Genetic Frontotemporal Initiative (GENFI) , Alberici , A , Cantoni , V , Gazzina , S , Archetti , S , Gasparotti , R , Fumagalli , G G , Bouzigues , A , Russell , L L , Samra , K , Cash , D M , Bocchetta , M , Todd , E G , Convery , R S , Swift , I , Sogorb-Esteve , A , Heller , C , van Swieten , J C , Jiskoot , L C , Seelaar , .... |
| سنة النشر: | 2024 |
| الوصف: | Background: The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment (MCBMI). The objective of the study was to validate the proposed research criteria for MCBMI-FTD in a cohort of genetically confirmed FTD cases against healthy controls. Methods: A total of 398 participants were enrolled, 117 of whom were carriers of an FTD pathogenic variant with mild clinical symptoms, while 281 were non-carrier family members (healthy controls (HC)). A subgroup of patients underwent blood neurofilament light (NfL) levels and anterior cingulate atrophy assessment. Results: The core clinical criteria correctly classified MCBMI vs HC with an AUC of 0.79 (p < 0.001), while the addition of either blood NfL or anterior cingulate atrophy significantly increased the AUC to 0.84 and 0.82, respectively (p < 0.001). The addition of both markers further increased the AUC to 0.90 (p < 0.001). Conclusions: The proposed MCBMI criteria showed very good classification accuracy for identifying the prodromal stage of FTD. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1186/s13195-024-01383-1 |
| الاتاحة: | https://pure.eur.nl/en/publications/dac1d0b4-d977-4c68-b17e-6f0548988a5a https://doi.org/10.1186/s13195-024-01383-1 https://pure.eur.nl/ws/files/127031457/s13195-024-01383-1.pdf http://www.scopus.com/inward/record.url?scp=85182168283&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.68EC0FD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13195-024-01383-1 |
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