التفاصيل البيبلوغرافية
| العنوان: |
Validated Filter-Based Photoreceptor Count Algorithm on Retinal Heidelberg High Magnification Module™ Images in Healthy and Pathological Conditions |
| المؤلفون: |
Timo Mulders, Patty Dhooge, Ludo van der Zanden, Carel B. Hoyng, Thomas Theelen |
| المصدر: |
Applied Sciences; Volume 11; Issue 12; Pages: 5347 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
high magnification module™, filter-based algorithm, manual cone counts, healthy subjects, central areolar choroidal dystrophy patients |
| جغرافية الموضوع: |
agris |
| الوصف: |
Recently introduced, the Heidelberg Engineering™ high magnification module enables in vivo visualization of cone photoreceptor cells. Currently, a reliable analysis of cone mosaic on high magnification module images is hindered by an unfavorable signal-to-noise ratio. In this paper, we describe how a novel high magnification module high-pass filter may enhance cone signals in healthy participants and patients. We compared the cone counts of our filter-based algorithm to the counts of two human graders. We found a good to excellent intragrader and intergrader correlation in both patients and healthy participants. We identified a good correlation between the average cone counts of both graders and high-pass filter cone counts in patients and healthy participants. We observed no significant difference between manual and filter-based counts via the Bland–Altman analysis. In conclusion, a quantitative cone analysis on high magnification module images is feasible manually by human graders and automatically by a filter-based algorithm. However, larger datasets are needed to improve repeatability and consistency by training human graders. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Applied Biosciences and Bioengineering; https://dx.doi.org/10.3390/app11125347 |
| DOI: |
10.3390/app11125347 |
| الاتاحة: |
https://doi.org/10.3390/app11125347 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.68C7B5D4 |
| قاعدة البيانات: |
BASE |