Academic Journal
Umbilical Cord Procalcitonin to Detect Early-Onset Sepsis in Newborns: A Promising Biomarker
| العنوان: | Umbilical Cord Procalcitonin to Detect Early-Onset Sepsis in Newborns: A Promising Biomarker |
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| المؤلفون: | Dongen, O. R. E., van Leeuwen, L. M., de Groot, P. K., Vollebregt, K., Schiering, I., Wevers, B. A., Euser, S. M., van Houten, M. A. |
| المصدر: | Frontiers in Pediatrics ; volume 9 ; ISSN 2296-2360 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2021 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Background: Up to 7% of neonates born in high-income countries receive antibiotics for suspected early-onset sepsis (EOS). Culture-proven neonatal sepsis has a prevalence of 0.2%, suggesting considerable overtreatment. We studied the diagnostic accuracy of umbilical cord blood and infant blood procalcitonin (PCT) in diagnosing EOS to improve antibiotic stewardship. Methods: Umbilical cord blood PCT was tested in newborns ≥ 32 weeks of gestation. Groups were defined as following: A) culture-proven or probable EOS ( n = 25); B) Possible EOS, based on risk factors for which antibiotics were administered for <72 h ( n = 49); C) Risk factor(s) for EOS without need for antibiotic treatment ( n = 181); D) Healthy controls ( n = 74). Additionally, venous or capillary blood PCT and C-reactive protein (CRP) were tested if blood drawing was necessary for standard care. Results: Between June 2019 and March 2021, 329 newborns were included. Umbilical cord blood PCT was significantly higher in group A than in group C and D. No difference between venous or arterial samples was found. Sensitivity and specificity for cord blood procalcitonin were 83 and 62%, respectively (cut-off 0.1 ng/mL). Antepartum maternal antibiotic administration was associated with decreased PCT levels in both cord blood and infant blood directly postpartum in all groups combined. Conclusion: Umbilical cord blood PCT levels are increased in newborns ≥32 weeks with a proven or probable EOS and low in newborns with risk factors for infection, but PCT seems not a reliable marker after maternal antibiotic treatment. PCT could be useful to distinguish infected from healthy newborns with or without EOS risk factors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fped.2021.779663 |
| DOI: | 10.3389/fped.2021.779663/full |
| الاتاحة: | http://dx.doi.org/10.3389/fped.2021.779663 https://www.frontiersin.org/articles/10.3389/fped.2021.779663/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.6897C3CA |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fped.2021.779663 |
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