التفاصيل البيبلوغرافية
| العنوان: |
Simultaneous Intracranial EEG-fMRI Shows Inter-Modality Correlation in Time-Resolved Connectivity Within Normal Areas but Not Within Epileptic Regions |
| المؤلفون: |
Ridley, Ben, Wirsich, Jonathan, Bettus, Gaelle, Rodionov, Roman, Murta, Teresa, Chaudhary, Umair, Carmichael, David, Thornton, Rachel, Vulliemoz, Serge, McEvoy, Andrew, Wendling, Fabrice, Bartolomei, Fabrice, Ranjeva, Jean-Philippe, Lemieux, Louis, Guye, Maxime |
| المصدر: |
ISSN: 0896-0267 ; Brain topography, vol. 30, no. 5 (2017) p. 639-655. |
| سنة النشر: |
2017 |
| المجموعة: |
Université de Genève: Archive ouverte UNIGE |
| مصطلحات موضوعية: |
info:eu-repo/classification/ddc/616.8, Adult, Brain/diagnostic imaging/physiopathology, Brain Mapping, Electroencephalography/methods, Epilepsy/diagnostic imaging/physiopathology, Female, Humans, Magnetic Resonance Imaging/methods, Male, Multimodal Imaging, Nerve Net/diagnostic imaging/physiopathology, Seizures/diagnostic imaging/physiopathology, Young Adult |
| الوصف: |
For the first time in research in humans, we used simultaneous icEEG-fMRI to examine the link between connectivity in haemodynamic signals during the resting-state (rs) and connectivity derived from electrophysiological activity in terms of the inter-modal connectivity correlation (IMCC). We quantified IMCC in nine patients with drug-resistant epilepsy (i) within brain networks in 'healthy' non-involved cortical zones (NIZ) and (ii) within brain networks involved in generating seizures and interictal spikes (IZ1) or solely spikes (IZ2). Functional connectivity (h 2 ) estimates for 10min of resting-state data were obtained between each pair of electrodes within each clinical zone for both icEEG and fMRI. A sliding window approach allowed us to quantify the variability over time of h 2 (vh 2) as an indicator of connectivity dynamics. We observe significant positive IMCC for h 2 and vh 2, for multiple bands in the NIZ only, with the strongest effect in the lower icEEG frequencies. Similarly, intra-modal h 2 and vh 2 were found to be differently modified as a function of different epileptic processes: compared to NIZ, [Formula: see text] was higher in IZ1, but lower in IZ2, while [Formula: see text] showed the inverse pattern. This corroborates previous observations of inter-modal connectivity discrepancies in pathological cortices, while providing the first direct invasive and simultaneous comparison in humans. We also studied time-resolved FC variability multimodally for the first time, finding that IZ1 shows both elevated internal [Formula: see text] and less rich dynamical variability, suggesting that its chronic role in epileptogenesis may be linked to greater homogeneity in self-sustaining pathological oscillatory states. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28194612; https://archive-ouverte.unige.ch/unige:124739; unige:124739 |
| الاتاحة: |
https://archive-ouverte.unige.ch/unige:124739 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: |
edsbas.683C1C4C |
| قاعدة البيانات: |
BASE |