Academic Journal
Chitosan-functionalized porous silicon optical transducer for the detection of carboxylic acid-containing drugs in water
| العنوان: | Chitosan-functionalized porous silicon optical transducer for the detection of carboxylic acid-containing drugs in water |
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| المؤلفون: | SCIACCA, BENIAMINO, PACE, STEPHANIE, GEOBALDO, FRANCESCO, Secret E., Gonzales P., Quignard F., Cunin F. |
| المساهمون: | Sciacca, Beniamino, Secret, E., Pace, Stephanie, Gonzales, P., Quignard, F., Geobaldo, Francesco, Cunin, F. |
| بيانات النشر: | Royal Society of Chemistry |
| سنة النشر: | 2011 |
| المجموعة: | PORTO@iris (Publications Open Repository TOrino - Politecnico di Torino) |
| مصطلحات موضوعية: | Carboxylic acid, Chitin, Chitosan, Experiment, Gas adsorption, Infrared spectroscopy, Oligomer, Transducers, Porous silicon |
| الوصف: | A chitosan/porous silicon biosensing platform for the detection of carboxylic acid-containing drugs in water is prepared and characterized. Parasitic layer-free films of mesoporous silicon are electrochemically etched and functionalized by covalent attachment of chitosan oligomers. The presence of the chitosan species covering the inner and outer surface of the porous silicon films is confirmed by infrared spectroscopy and nitrogen adsorption analysis. The obtained hybrid platform offers both an important porosity, with a higher surface area than the original porous silicon substrate, and an important surface charge, very suitable for sensing charged molecules. Ibuprofen is chosen as a drug model for the sensing experiments in water. Optical interferometry measurements are performed on the chitosan/porous silicon substrate exposed to ibuprofen solutions of various concentrations, and compared to the same experiments performed on a nonfunctionalized porous silicon surface. Results of the sensing experiments show that the presence of chitosan increases the sensitivity of the sensing porous film by more than one order of magnitude compared to the nonfunctionalized porous film. Detection in water of BHB, a model molecule for illicit rape drug GHB, is also demonstrated at concentrations compatible with forensic analysis, using the chitosan/porous silicon hybrid platform. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000286834600040; volume:3; issue:7; firstpage:2294; lastpage:2302; numberofpages:9; journal:JOURNAL OF MATERIALS CHEMISTRY; http://hdl.handle.net/11583/2376283 |
| DOI: | 10.1039/C0JM02904A |
| الاتاحة: | http://hdl.handle.net/11583/2376283 https://doi.org/10.1039/C0JM02904A |
| رقم الانضمام: | edsbas.683B75F0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1039/C0JM02904A |
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