Academic Journal
Early detection of high oxidative activity in patients with adenomatous intestinal polyps and colorectal adenocarcinoma: Myeloperoxidase and oxidized low-density lipoprotein in serum as new markers of oxidative stress in colorectal cancer
| العنوان: | Early detection of high oxidative activity in patients with adenomatous intestinal polyps and colorectal adenocarcinoma: Myeloperoxidase and oxidized low-density lipoprotein in serum as new markers of oxidative stress in colorectal cancer |
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| المؤلفون: | Crespo-Sanjuán, Jesús, Calvo-Rodríguez, María, Sánchez, Diego, Bajo-Grañeras, Raquel, García-Centeno, Rosa, Bustamante, Rosa, Garrote, José Antonio |
| المساهمون: | Junta de Castilla y León |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2015 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Oxidative stress, Cancer biomarkers, Antioxidants, Myeloperoxidase, LDL oxidized, Colorectal cancer |
| الوصف: | et al. ; [Objectives]: To detect whether signs of oxidative stress appear at early stages of colorectal adenocarcinoma (CRC), particularly in the polyp stage. We also aimed to evaluate the specific entities myeloperoxidase (MPO) and oxidized low-density lipoprotein (oxLDL) as novel markers of oxidation in the plasma of patients with CRC and to study the relationship between oxidative status in plasma and patient survival. [Methods]: We assayed serum or plasma specimens from healthy control subjects (n = 14), from patients with intestinal polyps (n = 39), and from patients with CRC (n = 128) to calculate the modified oxidative balance score (MOBS) using several serum markers (β-carotene, lycopene, vitamin A, vitamin E, MPO, and oxLDL). We also assayed the levels of C-reactive protein (CRP) and obtained lipid profiles. Finally, we studied the survival of patients in relationship to oxidative status (antioxidants and pro-oxidants) and inflammation markers, and added theses data to the lipid profile for each patient. [Results]: Oxidative stress levels increased as disease stage advanced. This increase was detected early in the polyp stage, before polyps progressed to cancer, and could be measured by the increase of such new markers as MPO and oxLDL, the decrease in antioxidants, and the MOBS value. Higher levels of oxidation correlated with lower survival. [Conclusion]: The oxidation process, which can cause mutations leading to CRC, begins development in the polyp stage. This process may be detected early by monitoring serum markers such as MPO and oxLDL. ; This work has been supported by grants to M.R.B. (JCyL GRS/278/A/08). ; Peer Reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0007-5027 |
| Relation: | Sí; e-issn: 1943-7730; Laboratory Medicine 46(2): 123-135 (2015); http://hdl.handle.net/10261/157686; http://dx.doi.org/10.13039/501100014180 |
| DOI: | 10.1309/LMZJJU6BC86WUDHW |
| DOI: | 10.13039/501100014180 |
| الاتاحة: | http://hdl.handle.net/10261/157686 https://doi.org/10.1309/LMZJJU6BC86WUDHW https://doi.org/10.13039/501100014180 |
| Rights: | none |
| رقم الانضمام: | edsbas.68248B3D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00075027 |
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| DOI: | 10.1309/LMZJJU6BC86WUDHW |