Academic Journal
Autoimmune Liver Diseases and Rheumatoid Arthritis—Is There an Etiopathogenic Link?
| العنوان: | Autoimmune Liver Diseases and Rheumatoid Arthritis—Is There an Etiopathogenic Link? |
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| المؤلفون: | Ioana Ruxandra Mihai, Ciprian Rezus, Maria Alexandra Burlui, Anca Cardoneanu, Luana Andreea Macovei, Patricia Richter, Ioana Bratoiu, Elena Rezus |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 7, p 3848 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | rheumatoid arthritis, autoimmune liver diseases, primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Rheumatoid arthritis (RA) is a systemic immune-mediated disease that, in addition to the articular involvement, can have extra-articular manifestations. Even though liver damage in RA is not very common, associated autoimmune liver diseases (AILDs) may occur. The most common AILD associated with RA is primary biliary cirrhosis (PBC), followed by autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC). There are common underlying mechanisms that play a role in the emergence of autoimmunity and inflammation in both rheumatic and autoimmune liver diseases. Genetic studies have revealed the existence of several common disease-associated genes shared between RA and AILDs, and infectious triggers, particularly those associated with recurrent or complicated urinary tract infections, are also speculated to be potential triggers for these conditions. Moreover, these diseases share common serologic patterns characterized by the presence of specific autoantibodies and hyper-gammaglobulinemia. In this study, we focus on reviewing the association between RA and AILDs regarding the prevalence and possible etiopathogenic link. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/7/3848; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/faee2ee90b0f45cbaafc76cd8a800840 |
| DOI: | 10.3390/ijms25073848 |
| الاتاحة: | https://doi.org/10.3390/ijms25073848 https://doaj.org/article/faee2ee90b0f45cbaafc76cd8a800840 |
| رقم الانضمام: | edsbas.681EB446 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25073848 |