Academic Journal
Prognostic value for long-term graft survival of estimated glomerular filtration rate and proteinuria quantified at 3 months after kidney transplantation
| العنوان: | Prognostic value for long-term graft survival of estimated glomerular filtration rate and proteinuria quantified at 3 months after kidney transplantation |
|---|---|
| المؤلفون: | Mottola, Clément, Girerd, Nicolas, Duarte, Kevin, Aarnink, Alice, Giral, Magali, Dantal, Jacques, Garrigue, Valérie, Mourad, Georges, Buron, Fanny, Morelon, Emmanuel, Ladrière, Marc, Kessler, Michèle, Frimat, Luc, Girerd, Sophie, Blancho, Gilles, Branchereau, Julien, Cantarovich, Diego, Chapelet, Agnès, Deltombe, Clément, Figueres, Lucile, Garandeau, Claire, Gourraud-Vercel, Caroline, Hourmant, Maryvonne, Karam, Georges, Kerleau, Clarisse, Meurette, Aurélie, Ville, Simon, Kandell, Christine, Moreau, Anne, Renaudin, Karine, Cesbron, Anne, Delbos, Florent, Walencik, Alexandre, Devis, Anne, Eschbach, Valérie, Eschwege, Pascal, Hubert, Jacques, Laurain, Emmanuelle, Leblanc, Louis, Lecoanet, Pierre, Lemelle, Jean-Louis, Badet, Lionel, Brunet, Maria, Cahen, Rémi, Daoud, Sameh, Fournie, Coralie, Grégoire, Arnaud, Koenig, Alice, Lévi, Charlène |
| المصدر: | Clinical Kidney Journal ; volume 13, issue 5, page 791-802 ; ISSN 2048-8513 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2020 |
| الوصف: | Background The estimated glomerular filtration rate (eGFR) measured at 1 year is the usual benchmark applied in kidney transplantation (KT). However, acting on earlier eGFR values could help in managing KT during the first post-operative year. We aimed to assess the prognostic value for long-term graft survival of the early (3 months) quantification of eGFR and proteinuria following KT. Methods The 3-, 6- and 12-month eGFR using the Modified Diet in Renal Disease equation (eGFRMDRD) was determined and proteinuria was measured in 754 patients who underwent their first KT between 2000 and 2010 (with a mean follow-up of 8.3 years) in our centre. Adjusted associations with graft survival were estimated using a multivariable Cox model. The predictive accuracy was estimated using the C-index and net reclassification index. These same analyses were measured in a multicentre validation cohort of 1936 patients. Results Both 3-month eGFRMDRD and proteinuria were independent predictors of return to dialysis (all P < 0.05) and there was a strong correlation between eGFR at 3 and 12 months (Spearman’s ρ = 0.76). The predictive accuracy of the 3-month eGFR was within a similar range and did not differ significantly from the 12-month eGFR in either the derivation cohort [C-index 62.6 (range 57.2–68.1) versus 66.0 (range 60.1–71.9), P = 0.41] or the validation cohort [C-index 69.3 (range 66.4–72.1) versus 71.7 (range 68.7–74.6), P = 0.25]. Conclusion The 3-month eGFR was a valuable predictor of the long-term return to dialysis whose predictive accuracy was not significantly less than that of the 12-month eGFR in multicentre cohorts totalling >2500 patients. Three-month outcomes may be useful in randomized controlled trials targeting early therapeutic interventions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ckj/sfaa044 |
| الاتاحة: | http://dx.doi.org/10.1093/ckj/sfaa044 http://academic.oup.com/ckj/article-pdf/13/5/791/33980628/sfaa044.pdf |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.6807504A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ckj/sfaa044 |
|---|