Academic Journal
Decrease of Interleukin-10-Producing T Cells in the Peripheral Blood of Severe Unstable Atopic Asthmatics
| العنوان: | Decrease of Interleukin-10-Producing T Cells in the Peripheral Blood of Severe Unstable Atopic Asthmatics |
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| المؤلفون: | Matsumoto, Koichiro, Inoue, Hiromasa, Fukuyama, Satoru, Tsuda, Miyuki, Ikegami, Tomomi, Kibe, Atsuko, Yoshiura, Yuki, Komori, Masashi, Hamasaki, Naotaka, Aizawa, Hisamichi, Nakanishi, Yoichi |
| المصدر: | International Archives of Allergy and Immunology ; volume 134, issue 4, page 295-302 ; ISSN 1018-2438 1423-0097 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2004 |
| الوصف: | Background: Although IL-10 is known as an immunoregulatory cytokine produced by various cells including T cells, its basic profile in atopic asthma remains uncertain. Objective: The profiles of IL-10 production in circulating CD4+ T cells of atopic asthmatics were investigated with respect to clinical severity. Methods: Forty atopic asthmatics were divided into three groups: mild, and severe but stable and severe unstable asthmatics. Eosinophils were counted in the peripheral blood and sputum, and exhaled nitric oxide was assessed. PBMCs were stimulated with or without anti-CD3 and anti-CD28 antibodies and then processed for detecting IL-10-producing CD4+ cells using flow cytometry. Results: There was no difference in the eosinophil count in blood or sputum and in nitric oxide level among the three groups. IL-10-producing CD4+ cells were mainly detected in a CD45RO+ memory population. The frequency of IL-10-producing cells after stimulation was significantly lower in the severe unstable group compared to the mild group. In addition, the frequency of IL-10-producing cells in the severe unstable group was significantly lower than that in the severe stable group despite the fact that both groups received similar treatments with high-dose inhaled corticosteroids. The IL-10 production of CD4+CD45RO+ cells in response to dexamethasone did not differ among the three groups. Conclusions: IL-10-producing CD4+CD45RO+ cells in the peripheral blood are decreased in severe unstable asthmatics, which is not explained by the effect of high-dose inhaled corticosteroid medication. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000079167 |
| الاتاحة: | http://dx.doi.org/10.1159/000079167 https://www.karger.com/Article/Pdf/79167 |
| Rights: | https://www.karger.com/Services/SiteLicenses ; https://www.karger.com/Services/SiteLicenses |
| رقم الانضمام: | edsbas.67DBB2E5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000079167 |
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