Academic Journal
Origins of Selectivity in Glycosylation Reactions with Saccharosamine Donors
| العنوان: | Origins of Selectivity in Glycosylation Reactions with Saccharosamine Donors |
|---|---|
| المؤلفون: | Brian P. Garreffi, Ryan W. Kwok, Mateusz Marianski, Clay S. Bennett |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biochemistry, Genetics, Molecular Biology, Evolutionary Biology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, linked reactive intermediates, deoxy sugar saccharosamine, n , saccharosamine donors, distinct intermediates, studies show, stereochemical outcome, like mechanism, glycosylation reactions, either α, differential modes, dft calculations, activation lead |
| الوصف: | A combination of DFT calculations and experiments is used to describe how the selection of a promoter can control the stereochemical outcome of glycosylation reactions with the deoxy sugar saccharosamine. Depending on the promoter, either α- or β-linked reactive intermediates are formed. These studies show that differential modes of activation lead to the formation of distinct intermediates that undergo highly selective reactions through an S N 2-like mechanism. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Origins_of_Selectivity_in_Glycosylation_Reactions_with_Saccharosamine_Donors/24763956 |
| DOI: | 10.1021/acs.orglett.3c03607.s001 |
| الاتاحة: | https://doi.org/10.1021/acs.orglett.3c03607.s001 https://figshare.com/articles/journal_contribution/Origins_of_Selectivity_in_Glycosylation_Reactions_with_Saccharosamine_Donors/24763956 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.67BF85FD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.orglett.3c03607.s001 |
|---|