Academic Journal
Brain Temperature Influences Intracranial Pressure and Cerebral Perfusion Pressure After Traumatic Brain Injury: A CENTER-TBI Study.
| العنوان: | Brain Temperature Influences Intracranial Pressure and Cerebral Perfusion Pressure After Traumatic Brain Injury: A CENTER-TBI Study. |
|---|---|
| المؤلفون: | Birg, Tatiana, Ortolano, Fabrizio, Wiegers, Eveline JA, Smielewski, Peter, Savchenko, Yan, Ianosi, Bogdan A, Helbok, Raimund, Rossi, Sandra, Carbonara, Marco, Zoerle, Tommaso, Stocchetti, Nino, CENTER-TBI Investigators and Participants |
| بيانات النشر: | Springer Science and Business Media LLC //dx.doi.org/10.1007/s12028-021-01294-1 Neurocrit Care |
| سنة النشر: | 2022 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Brain temperature, Cerebral perfusion pressure, Fever, Hyperthermia, Intracranial pressure, Neuromonitoring, Traumatic brain injury, Brain, Brain Injuries, Traumatic, Cerebrovascular Circulation, Humans, Intracranial Hypertension, Longitudinal Studies, Prospective Studies, Temperature |
| الوصف: | Funder: Università degli Studi di Milano ; BACKGROUND: After traumatic brain injury (TBI), fever is frequent. Brain temperature (BT), which is directly linked to body temperature, may influence brain physiology. Increased body and/or BT may cause secondary brain damage, with deleterious effects on intracranial pressure (ICP), cerebral perfusion pressure (CPP), and outcome. METHODS: Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI), a prospective multicenter longitudinal study on TBI in Europe and Israel, includes a high resolution cohort of patients with data sampled at a high frequency (from 100 to 500 Hz). In this study, simultaneous BT, ICP, and CPP recordings were investigated. A mixed-effects linear model was used to examine the association between different BT levels and ICP. We additionally focused on changes in ICP and CPP during the episodes of BT changes (Δ BT ≥ 0.5 °C lasting from 15 min to 3 h) up or downward. The significance of ICP and CPP variations was estimated with the paired samples Wilcoxon test (also known as Wilcoxon signed-rank test). RESULTS: Twenty-one patients with 2,435 h of simultaneous BT and ICP monitoring were studied. All patients reached a BT of 38 °C and experienced at least one episode of ICP above 20 mm Hg. The linear mixed-effects model revealed an association between BT above 37.5 °C and higher ICP levels that was not confirmed for lower BT. We identified 149 episodes of BT changes. During BT elevations (n = 79) ICP increased, whereas CPP was reduced; opposite ICP and CPP variations occurred during episodes of BT reduction (n = 70). All these changes were of moderate clinical relevance (increase of ICP of 4.5 and CPP decrease of 7.5 mm Hg for BT rise, and ICP reduction of 1.7 and CPP elevation of 3.7 mm Hg during BT defervescence), even if statistically significant (p < 0.0001). It has to be noted, however, that a number of therapeutic interventions against intracranial hypertension was documented during those episodes. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/xml; application/pdf |
| اللغة: | English |
| Relation: | https://www.repository.cam.ac.uk/handle/1810/332064 |
| DOI: | 10.17863/CAM.79511 |
| الاتاحة: | https://www.repository.cam.ac.uk/handle/1810/332064 https://doi.org/10.17863/CAM.79511 |
| رقم الانضمام: | edsbas.67A768AD |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.79511 |
|---|