Academic Journal
Peripheral GABAA receptors - Physiological relevance and therapeutic implications
| العنوان: | Peripheral GABAA receptors - Physiological relevance and therapeutic implications |
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| المؤلفون: | Gajić Bojić, Milica, Aranđelović, Jovana, Škrbić, Ranko, Savić, Miroslav |
| المصدر: | Pharmacology and Therapeutics |
| بيانات النشر: | Elsevier Inc. |
| سنة النشر: | 2025 |
| المجموعة: | FarFaR - Pharmacy Repository (Univ. of Belgrade, Fac. of Pharmacy) |
| مصطلحات موضوعية: | GABAA receptor subunits, Peripheral GABAA receptors, Peripheral organs |
| الوصف: | The role of γ- aminobutyric acid (GABA) and GABAA receptors is not only essential for neurotransmission in the central nervous system (CNS), but they are also involved in communication in various peripheral tissues such as the pancreas, liver, kidney, gastrointestinal tract, trachea, immune cells and blood vessels. GABAA receptors located outside the CNS (“peripheral GABAA receptors”) enable both neuronal and non-neuronal GABA-ergic signaling in various physiological processes and are generally thought to have similar properties to the extrasynaptic receptors in the CNS. By activating these peripheral receptors, GABA and various GABAA receptor modulators, including drugs such as benzodiazepines and general anesthetics, may contribute to or otherwise affect the maintenance of general body homeostasis. However, the existing data in the literature on the role of non-neuronal GABA-ergic signaling in insulin secretion, glucose metabolism, renal function, intestinal motility, airway tone, immune response and blood pressure regulation are far from complete. In fact, they mainly focus on the identification of components for the local synthesis and utilization of GABA and on the expression repertoire of GABAA receptor subunits rather than on subunit composition, activation effects and (sub)cellular localization. A deeper understanding of how modulation of peripheral GABAA receptors can have significant therapeutic effects on a range of pathological conditions such as multiple sclerosis, diabetes, irritable bowel syndrome, asthma or hypertension could contribute to the development of more specific pharmacological strategies that would provide an alternative or complement to existing therapies. Selective GABAA receptor modulators with improved peripheral efficacy and reduced central side effects would therefore be highly desirable first-in-class drug candidates. This review updates recent advances unraveling the molecular components and cellular determinants of the GABA signaling machinery in peripheral organs, tissues and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | info:eu-repo/grantAgreement/ScienceFundRS/Ideje/7749108/RS//; NanoCellEmoCog; https://farfar.pharmacy.bg.ac.rs/handle/123456789/5872; 001383378300001 |
| DOI: | 10.1016/j.pharmthera.2024.108759 |
| الاتاحة: | https://farfar.pharmacy.bg.ac.rs/handle/123456789/5872 https://doi.org/10.1016/j.pharmthera.2024.108759 |
| Rights: | restrictedAccess ; ARR |
| رقم الانضمام: | edsbas.6790163D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.pharmthera.2024.108759 |
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