التفاصيل البيبلوغرافية
| العنوان: |
The German keratomycosis registry. Initial results of a multicenter survey |
| المؤلفون: |
Roth, M., Daas, L., Renner-Wilde, A., Cvetkova-Fischer, N., Saeger, M., Herwig-Carl, M., Matthaei, M., Fekete, A., Kakkassery, V., Walther, G., von Lilienfeld-Toal, M., Mertens, C., Lenk, J., Mehlan, J., Fischer, C., Fuest, M., Kroll, S., Bayoudh, W., Viestenz, A., Frings, A., MacKenzie, C. R., Messmer, E. M., Seitz, B., Kurzai, O., Geerling, G. |
| بيانات النشر: |
SPRINGER HEIDELBERG |
| سنة النشر: |
2019 |
| المجموعة: |
Cologne University: KUPS |
| مصطلحات موضوعية: |
ddc:no |
| الوصف: |
Background and purpose. Mycotic keratitis is a serious but relatively rare disease. No targeted data collection in Germany existed until the foundation of the German Pilz-Keratitis Register in 2015. Patients and methods. The inclusion of retrospective and prospective patients was carried out. Inclusion criteria: diagnosis confirmed by the polymerase chain reaction (PCR), culture, histology or confocal microscopy (IVCM). Collected parameters: date of symptom onset, date and method of diagnosis, risk factors, visual acuity and findings at admission and at follow-up, conservative and surgical treatment. Results. By January 2018, a total of 102 eyes from the years 2000-2017 were reported from 16 centers (64.3% female, mean age 52 years, range 18-95 years). The initial diagnosis was made correctly in only 20.6% of cases. The mean time to correct diagnosis was 31.7 +/- 46.9 (0-296) days. The diagnosis was confirmed in cultures in 74.5%, histologically in 30.4%, by PCR in 38.2% and IVCM in 27.4%. Fungal species identified were: 36.7% Fusarium spp., 35.8% Candida spp., 6.4% Aspergillus spp. and 21.1% other. The most important risk factor was the use of contact lenses. The most commonly used antifungal agent was voriconazole (64.7%) followed by amphotericin B (37.2%). Penetrating keratoplasty was performed in 65.7% of the cases and 8.8% of the affected eyes had to be enucleated. The visual acuity of the entire study population increased from the initial 0.16 +/- 0.25 (0.001-1.0) decimal to 0.28 +/- 0.34 (0-1.0) decimal. Conclusion. The correct diagnosis of fungal keratitis is often significantly delayed. The treatment can be very difficult and keratoplasty is often necessary. In order to gain a better understanding of this disease, to recognize previously unknown risk factors and, if necessary, a change in the spectrum of pathogens and to identify approaches to treatment optimization, the fungal keratitis registry will be continued. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
German |
| Relation: |
Roth, M., Daas, L., Renner-Wilde, A., Cvetkova-Fischer, N., Saeger, M., Herwig-Carl, M., Matthaei, M., Fekete, A., Kakkassery, V., Walther, G., von Lilienfeld-Toal, M., Mertens, C., Lenk, J., Mehlan, J., Fischer, C., Fuest, M., Kroll, S., Bayoudh, W., Viestenz, A., Frings, A., MacKenzie, C. R., Messmer, E. M., Seitz, B., Kurzai, O. and Geerling, G. (2019). The German keratomycosis registry. Initial results of a multicenter survey. Ophthalmologe, 116 (10). S. 957 - 967. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0423 |
| الاتاحة: |
https://kups.ub.uni-koeln.de/13160/ |
| رقم الانضمام: |
edsbas.677F238A |
| قاعدة البيانات: |
BASE |