Academic Journal
Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK):a prospective observational study
| العنوان: | Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK):a prospective observational study |
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| المؤلفون: | Geretti, Anna Maria, Stockdale, Alexander J, Kelly, Sophie H, Cevik, Muge, Collins, Simon, Waters, Laura, Villa, Giovanni, Docherty, Annemarie, Harrison, Ewen M, Turtle, Lance, Openshaw, Peter J M, Baillie, J Kenneth, Sabin, Caroline A, Semple, Malcolm G |
| المصدر: | Geretti , A M , Stockdale , A J , Kelly , S H , Cevik , M , Collins , S , Waters , L , Villa , G , Docherty , A , Harrison , E M , Turtle , L , Openshaw , P J M , Baillie , J K , Sabin , C A & Semple , M G 2021 , ' Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK) : a prospective observational study ' , Clinical Infectious Diseases , vol. 73 , no. .... |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | COVID-19, SARS-CoV-2, HIV, Mortality |
| الوصف: | BACKGROUND: Evidence is conflicting about how HIV modulates COVID-19. We compared the presentation characteristics and outcomes of adults with and without HIV who were hospitalized with COVID-19 at 207 centers across the United Kingdom and whose data were prospectively captured by the ISARIC WHO CCP study. METHODS: We used Kaplan-Meier methods and Cox regression to describe the association between HIV status and day-28 mortality, after separate adjustment for sex, ethnicity, age, hospital acquisition of COVID-19 (definite hospital acquisition excluded), presentation date, ten individual comorbidities, and disease severity at presentation (as defined by hypoxia or oxygen therapy). RESULTS: Among 47,592 patients, 122 (0.26%) had confirmed HIV infection and 112/122 (91.8%) had a record of antiretroviral therapy. At presentation, HIV-positive people were younger (median 56 versus 74 years; p<0.001) and had fewer comorbidities, more systemic symptoms and higher lymphocyte counts and C-reactive protein levels. The cumulative day-28 mortality was similar in the HIV-positive vs. HIV-negative groups (26.7% vs. 32.1%; p=0.16), but in those under 60 years of age HIV-positive status was associated with increased mortality (21.3% vs. 9.6%; p<0.001 [log-rank test]). Mortality was higher among people with HIV after adjusting for age (adjusted hazard ratio [aHR] 1.47, 95% confidence interval [CI] 1.01-2.14; p=0.05), and the association persisted after adjusting for the other variables (aHR 1.69; 95% CI 1.15-2.48; p=0.008) and when restricting the analysis to people aged <60 years (aHR 2.87; 95% CI 1.70-4.84; p<0.001). CONCLUSIONS: HIV-positive status was associated with an increased risk of day-28 mortality among patients hospitalized for COVID-19. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1093/cid/ciaa1605 |
| DOI: | 10.1093/cid/ciaa1605/5937133#supplementary-data |
| الاتاحة: | https://risweb.st-andrews.ac.uk/portal/en/researchoutput/outcomes-of-covid19-related-hospitalization-among-people-with-hiv-in-the-isaric-who-clinical-characterization-protocol-uk(ec625111-85aa-4d1b-bacf-b8d0e51e55fb).html https://doi.org/10.1093/cid/ciaa1605 https://research-repository.st-andrews.ac.uk/bitstream/10023/20946/2/Geretti_2020_CID_OutcomesCovid_19_CC.pdf https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1605/5937133#supplementary-data |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.677AC26F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/cid/ciaa1605 |
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