Academic Journal
The Antimicrobial Activity of Micron-Thin Sol-Gel Films Loaded with Linezolid and Cefoxitin for Local Prevention of Orthopedic Prosthesis-Related Infections
| العنوان: | The Antimicrobial Activity of Micron-Thin Sol-Gel Films Loaded with Linezolid and Cefoxitin for Local Prevention of Orthopedic Prosthesis-Related Infections |
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| المؤلفون: | Toirac Chavez, Beatriz Dunia, Aguilera-Correa, John Jairo, Mediero, Aranzazu, Esteban, Jaime, Jiménez Morales, Antonia |
| المساهمون: | Comunidad de Madrid, Ministerio de Educación, Cultura y Deporte (España) |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Universidad Carlos III de Madrid: e-Archivo |
| مصطلحات موضوعية: | Cefoxitin, Electrochemical Impedance Spectroscopy, Escherichia Coli, Linezolid, Nanogels, Prosthesis-Related Infections, Sol-Gel Coating, Staphylococcus Aureus, Staphylococcus Epidermidis, Materiales, Química |
| الوصف: | Orthopedic prosthesis-related infections (OPRI) are an essential health concern. OPRI prevention is a priority and a preferred option over dealing with poor prognosis and high-cost treatments. Micron-thin sol–gel films have been noted for a continuous and effective local delivery system. This study aimed to perform a comprehensive in vitro evaluation of a novel hybrid organic–inorganic sol–gel coating developed from a mixture of organopolysiloxanes and organophosphite and loaded with different concentrations of linezolid and/or cefoxitin. The kinetics of degradation and antibiotics release from the coatings were measured. The inhibition of biofilm formation of the coatings against Staphylococcus aureus, S. epidermidis, and Escherichia coli strains was studied, as well as the cell viability and proliferation of MC3T3-E1 osteoblasts. The microbiological assays demonstrated that sol–gel coatings inhibited the biofilm formation of the evaluated Staphylococcus species; however, no inhibition of the E. coli strain was achieved. A synergistic effect of the coating loaded with both antibiotics was observed against S. aureus. The cell studies showed that the sol–gels did not compromise cell viability and proliferation. In conclusion, these coatings represent an innovative therapeutic strategy with potential clinical use to prevent staphylococcal OPRI. ; Funding: This research was funded by the Regional Government of Madrid through the program ADITIMAT (ref. P2018/NMT-4411) and CIBERINFEC-CIBER of Infectious Diseases (CB21/13/00043). B.T. would like to thank the Spanish Ministry of Education, Culture, and Sports for the support through the FPU grant (FPU17/05977). ; Publicado |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2310-2861 |
| Relation: | Comunidad de Madrid. P2018/NMT-4411/ADITIMAT; Comunidad de Madrid. CB21/13/00043/CIBERINFEC-CIBER; Gobierno de España. FPU17/05977; Toirac B, Aguilera-Correa JJ, Mediero A, Esteban J, Jiménez-Morales A. The Antimicrobial Activity of Micron-Thin Sol–Gel Films Loaded with Linezolid and Cefoxitin for Local Prevention of Orthopedic Prosthesis-Related Infections. Gels. 2023; 9(3):176, (19p.). https://doi.org/10.3390/gels9030176; http://hdl.handle.net/10016/38833; https://doi.org/10.3390/gels9030176; 3, 176; 19; Gels; AR/0000033465 |
| DOI: | 10.3390/gels9030176 |
| الاتاحة: | http://hdl.handle.net/10016/38833 https://doi.org/10.3390/gels9030176 |
| Rights: | © 2023 by the authors. ; Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ; Atribución-NoComercial-SinDerivadas 3.0 España ; http://creativecommons.org/licenses/by-nc-nd/3.0/es/ ; open access |
| رقم الانضمام: | edsbas.6734EABA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23102861 |
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| DOI: | 10.3390/gels9030176 |