التفاصيل البيبلوغرافية
| العنوان: |
Data_Sheet_1_OXA-830, a Novel Chromosomally Encoded Extended-Spectrum Class D β-Lactamase in Aeromonas simiae.docx |
| المؤلفون: |
Qianqian Chen, Wangxiao Zhou, Changrui Qian, Kai Shen, Xinyi Zhu, Danying Zhou, Zhewei Sun, Wei Lu, Hongmao Liu, Kewei Li, Teng Xu, Qiyu Bao, Junwan Lu |
| سنة النشر: |
2019 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Microbiology, Microbial Genetics, Microbial Ecology, Mycology, oxacillinase, OXA-830, Aeromonas simiae, resistance, kinetic analysis |
| الوصف: |
The diversity of class D β-lactamases mediating resistance to β-lactams has been increasingly reported recently. In this study, a novel class D oxacillinase named OXA-830 was identified in a fully sequenced Aeromonas simiae strain, which was isolated from sewage discharged from a farm in southern China. OXA-830 shares the highest amino acid identity of 79.3% with an OXA-12-like variant named OXA-725. When expressed in E. coli DH5α, OXA-830 conferred resistance to penicillins and selected β-lactamase inhibitors but not to cephalosporins and carbapenems. Kinetic analysis of OXA-830 revealed a broad substrate profile including penicillins, cefazolin, cefoxitin, and ceftazidime but not carbapenems. The hydrolytic activity was significantly inhibited by sulbactam, followed by tazobactam, but was less effectively inhibited by clavulanic acid. The bla OXA– 830 gene was located on the A. simiae A6 chromosome and the bla OXA– 830 -related region was bracketed by a pair of perfect inverted repeats. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Data_Sheet_1_OXA-830_a_Novel_Chromosomally_Encoded_Extended-Spectrum_Class_D_-Lactamase_in_Aeromonas_simiae_docx/11161280 |
| DOI: |
10.3389/fmicb.2019.02732.s001 |
| الاتاحة: |
https://doi.org/10.3389/fmicb.2019.02732.s001
https://figshare.com/articles/dataset/Data_Sheet_1_OXA-830_a_Novel_Chromosomally_Encoded_Extended-Spectrum_Class_D_-Lactamase_in_Aeromonas_simiae_docx/11161280 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.67300926 |
| قاعدة البيانات: |
BASE |