Academic Journal
Does an antibiotic-loaded hydrogel coating reduce early post-surgical infection after joint arthroplasty?
| العنوان: | Does an antibiotic-loaded hydrogel coating reduce early post-surgical infection after joint arthroplasty? |
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| المؤلفون: | Romano, CL, Malizos, K, Capuano, N, Mezzoprete, R, D'Arienzo, M, Scarponi, S, Van Der Straeten, C, Drago, L |
| المساهمون: | European Commission FP7 |
| المصدر: | 41 ; 34 |
| بيانات النشر: | Ivyspring International Publisher |
| سنة النشر: | 2016 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | infection, joint prosthesis |
| الوصف: | Background: Infection remains among the main reasons for joint prosthesis failure. Preclinical reports have suggested that antibacterial coatings of implants may prevent bacterial adhesion and biofilm formation. This study presents the results of the first clinical trial on an antibiotic-loaded fast-resorbable hydrogel coating (Defensive Antibacterial Coating, DAC®) in patients undergoing hip or knee prosthesis. Methods: In this multicenter, randomized prospective study, a total of 380 patients, scheduled to undergo primary (n=270) or revision (n=110) total hip (N=298) or knee (N=82) joint replacement with a cementless or a hybrid implant, were randomly assigned, in six European orthopedic centers, to receive an implant either with the antibiotic-loaded DAC coating (treatment group) or without coating (control group). Pre- and postoperative assessment of clinical scores, wound healing, laboratory tests, and x-ray exams were performed at fixed time intervals. Results: Overall, 373 patients were available at a mean follow-up of 14.5 ± 5.5 months (range 6 to 24). On average, wound healing, laboratory and radiographic findings showed no significant difference between the two groups. Eleven early surgical site infections were observed in the control group and only one in the treatment group (6% vs. 0.6%; p=0.003). No local or systemic side effects related to the DAC hydrogel coating were observed, and no detectable interference with implant osteointegration was noted. Conclusions: The use of a fast-resorbable, antibiotic-loaded hydrogel implant coating can reduce the rate of early surgical site infections, without any detectable adverse events or side effects after hip or knee joint replacement with a cementless or hybrid implant. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 2206-3552 |
| Relation: | Journal of Bone and Joint Infection; http://hdl.handle.net/10044/1/48170; https://dx.doi.org/10.7150/jbji.15986; EU FP7-HEALTH-2011-two-stage project Implant Disposable Antibacterial Coating (I.D.A.C.) |
| DOI: | 10.7150/jbji.15986 |
| الاتاحة: | http://hdl.handle.net/10044/1/48170 https://doi.org/10.7150/jbji.15986 |
| Rights: | © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attri bution (CC BY-NC) license (https://cr eativecommons.org/licenses/by-nc/4.0/). |
| رقم الانضمام: | edsbas.672734A9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22063552 |
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| DOI: | 10.7150/jbji.15986 |