Academic Journal
Rfx6 directs islet formation and insulin production in mice and humans
| العنوان: | Rfx6 directs islet formation and insulin production in mice and humans |
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| المؤلفون: | Smith, Stuart B., Qu, Hui Qi, Taleb, Nadine, Kishimoto, Nina Y., Scheel, David W., Lu, Yang, Patch, Ann Marie, Grabs, Rosemary, Wang, Juehu, Lynn, Francis C., Miyatsuka, Takeshi, Mitchell, John, Seerke, Rina, Désir, Julie, Eijnden, Serge Vanden, Abramowicz, Marc, Kacet, Nadine, Weill, Jacques, Renard, Marie Éve, Gentile, Mattia, Hansen, Inger, Dewar, Ken, Hattersley, Andrew T., Wang, Rennian, Wilson, Maria E., Johnson, Jeffrey D. |
| المصدر: | Paediatrics Publications |
| بيانات النشر: | Scholarship@Western |
| سنة النشر: | 2010 |
| المجموعة: | The University of Western Ontario: Scholarship@Western |
| الوصف: | Insulin from the Β-cells of the pancreatic islets of Langerhans controls energy homeostasis in vertebrates, and its deficiency causes diabetes mellitus. During embryonic development, the transcription factor neurogenin 3 (Neurog3) initiates the differentiation of the Β-cells and other islet cell types from pancreatic endoderm, but the genetic program that subsequently completes this differentiation remains incompletely understood. Here we show that the transcription factor Rfx6 directs islet cell differentiation downstream of Neurog3. Mice lacking Rfx6 failed to generate any of the normal islet cell types except for pancreatic-polypeptide-producing cells. In human infants with a similar autosomal recessive syndrome of neonatal diabetes, genetic mapping and subsequent sequencing identified mutations in the human RFX6 gene. These studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans. Rfx6 could prove useful in efforts to generate Β-cells for patients with diabetes. © 2010 Macmillan Publishers Limited. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | https://ir.lib.uwo.ca/paedpub/2469; https://ir.lib.uwo.ca/context/paedpub/article/3477/viewcontent/nihms_165700.pdf |
| DOI: | 10.1038/nature08748 |
| الاتاحة: | https://ir.lib.uwo.ca/paedpub/2469 https://doi.org/10.1038/nature08748 https://ir.lib.uwo.ca/context/paedpub/article/3477/viewcontent/nihms_165700.pdf |
| رقم الانضمام: | edsbas.6721F44C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/nature08748 |
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