Academic Journal
Sex-Specific Transcriptomic Changes in the Villous Tissue of Placentas of Pregnant Women Using a Selective Serotonin Reuptake Inhibitor
| العنوان: | Sex-Specific Transcriptomic Changes in the Villous Tissue of Placentas of Pregnant Women Using a Selective Serotonin Reuptake Inhibitor |
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| المؤلفون: | Laura Staal, Torsten Plösch, Theodora Kunovac Kallak, Inger Sundström Poromaa, Bregje Wertheim, Jocelien D. A. Olivier |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Cell Biology, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Immunology, Developmental Biology, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, neural embryonic development, extracellular matrix organization, assessing whole transcriptomes, six male infants, male infants born, specific transcriptomic changes, identified genes related, differentially expressed genes, six female infants, pregnant women using, without ssri treatment, female infants, specific analyses, pregnant women, ssri treatment, well understood, villous tissue, significantly enriched, rna sequencing |
| الوصف: | About 5% of pregnant women are treated with selective serotonin reuptake inhibitor (SSRI) antidepressants to treat their depression. SSRIs influence serotonin levels, a key factor in neural embryonic development, and their use during pregnancy has been associated with adverse effects on the developing embryo. However, the role of the placenta in transmitting these negative effects is not well understood. In this study, we aim to elucidate how disturbances in the maternal serotonergic system affect the villous tissue of the placenta by assessing whole transcriptomes in the placentas of women with healthy pregnancies and women with depression and treated with the SSRI fluoxetine during pregnancy. Twelve placentas of the Biology, Affect, Stress, Imaging and Cognition in Pregnancy and the Puerperium (BASIC) project were selected for RNA sequencing to examine differentially expressed genes: six male infants and six female infants, equally distributed over women treated with SSRI and without SSRI treatment. Our results show that more genes in the placenta of male infants show changed expression associated with fluoxetine treatment than in placentas of female infants, stressing the importance of sex-specific analyses. In addition, we identified genes related to extracellular matrix organization to be significantly enriched in placentas of male infants born to women treated with fluoxetine. It remains to be established whether the differentially expressed genes that we found to be associated with SSRI treatment are the result of the SSRI treatment itself, the underlying depression, or a combination of the two. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Sex-Specific_Transcriptomic_Changes_in_the_Villous_Tissue_of_Placentas_of_Pregnant_Women_Using_a_Selective_Serotonin_Reuptake_Inhibitor/25317956 |
| DOI: | 10.1021/acschemneuro.3c00621.s001 |
| الاتاحة: | https://doi.org/10.1021/acschemneuro.3c00621.s001 https://figshare.com/articles/journal_contribution/Sex-Specific_Transcriptomic_Changes_in_the_Villous_Tissue_of_Placentas_of_Pregnant_Women_Using_a_Selective_Serotonin_Reuptake_Inhibitor/25317956 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.671B8718 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acschemneuro.3c00621.s001 |
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