Academic Journal
Infant and Adult Gut Microbiome and Metabolome in Rural Bassa and Urban Settlers from Nigeria
| العنوان: | Infant and Adult Gut Microbiome and Metabolome in Rural Bassa and Urban Settlers from Nigeria |
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| المؤلفون: | Ayeni, Funmilola A., Biagi, Elena, Rampelli, Simone, Fiori, Jessica, Soverini, Matteo, Audu, Haruna J., Cristino, Sandra, Caporali, Leonardo, Schnorr, Stephanie L., Carelli, Valerio, Brigidi, Patrizia, Candela, Marco, Turroni, Silvia |
| المساهمون: | Ayeni, Funmilola A.*, Biagi, Elena, Rampelli, Simone, Fiori, Jessica, Soverini, Matteo, Audu, Haruna J., Cristino, Sandra, Caporali, Leonardo, Schnorr, Stephanie L., Carelli, Valerio, Brigidi, Patrizia, Candela, Marco, Turroni, Silvia |
| سنة النشر: | 2018 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | gut microbiota, human evolution, infant microbiome, metabolome, microbial dispersal, subsistence pattern, urbanization, Biochemistry, Genetics and Molecular Biology (all) |
| الوصف: | We assessed the subsistence-related variation of the human gut microbiome at a fine resolution for two of the main dimensions of microbiome variation, age and geography. For this, we investigated the fecal microbiome and metabolome in rural Bassa and urbanized individuals from Nigeria, including infants, and compared data with worldwide populations practicing varying subsistence. Our data highlight specific microbiome traits that are progressively lost with urbanization, such as the dominance of pristine fiber degraders and the low inter-individual variation. For the Bassa, this last feature is the result of their subsistence-related practices favoring microbial dispersal, such as their extensive environmental contact and the usage of untreated waters from the Usuma River. The high degree of microbial dispersal observed in the Bassa meta-community nullifies the differences between infant and adult intestinal ecosystems, suggesting that the infant-type microbiome in Western populations could be the result of microbiome-associated neotenic traits favored by urbanization. Ayeni et al. characterize the fecal microbiome and metabolome of rural Bassa and urban individuals from Nigeria, including infants. Their findings stress the loss of ancient signatures along with urbanization and support distinct trajectories of development of the intestinal ecosystem in early life, depending on human subsistence. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/29874590; info:eu-repo/semantics/altIdentifier/wos/WOS:000434982000020; volume:23; issue:10; firstpage:3056; lastpage:3067; numberofpages:12; journal:CELL REPORTS; http://hdl.handle.net/11585/644405; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85047459927; http://www.sciencedirect.com/science/journal/22111247 |
| DOI: | 10.1016/j.celrep.2018.05.018 |
| الاتاحة: | http://hdl.handle.net/11585/644405 https://doi.org/10.1016/j.celrep.2018.05.018 http://www.sciencedirect.com/science/journal/22111247 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.66DF2275 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2018.05.018 |
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