Academic Journal
Generation of Best disease-derived induced pluripotent stem cell line (FRIMOi006-A) carrying a novel dominant mutation in BEST1 gene
| العنوان: | Generation of Best disease-derived induced pluripotent stem cell line (FRIMOi006-A) carrying a novel dominant mutation in BEST1 gene |
|---|---|
| المؤلفون: | Judit Domingo-Prim, Marina Riera, Víctor Abad-Morales, Sheila Ruiz-Nogales, Borja Corcostegui, Esther Pomares |
| المصدر: | Stem Cell Research, Vol 40, Iss , Pp - (2019) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2019 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Biology (General), QH301-705.5 |
| الوصف: | Best disease, also known as Best vitelliform macular dystrophy, is an autosomal dominant form of macular degeneration. Here, we have generated an induced pluripotent stem cell (iPSC) line derived from a Best disease patient carrying a new dominant mutation in the BEST1 gene. Skin fibroblasts were reprogrammed to iPSCs by the non-integrative Sendai-virus method. The iPSC line has been characterized preserving the BEST1 mutation, expressing the pluripotency markers and being capable to differentiate to endoderm, mesoderm and ectoderm in vitro. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1873-5061 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1873506119302004; https://doaj.org/toc/1873-5061; https://doaj.org/article/8b3b5105d92048eba75d69621c8ddd4b |
| DOI: | 10.1016/j.scr.2019.101570 |
| الاتاحة: | https://doi.org/10.1016/j.scr.2019.101570 https://doaj.org/article/8b3b5105d92048eba75d69621c8ddd4b |
| رقم الانضمام: | edsbas.66A7F7FB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 18735061 |
|---|---|
| DOI: | 10.1016/j.scr.2019.101570 |