Academic Journal
CD4 cell count response to first-line combination ART in HIV-2+ patients compared with HIV-1+ patients: a multinational, multicohort European study
| العنوان: | CD4 cell count response to first-line combination ART in HIV-2+ patients compared with HIV-1+ patients: a multinational, multicohort European study |
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| المؤلفون: | Wittkop, L, Arsandaux, J, Trevino, A, Böni, Jürg, Calmy, A, COHERE in EuroCoord, ACHIeV2e Study Group |
| المصدر: | Wittkop, L; Arsandaux, J; Trevino, A; et al; Böni, Jürg; Calmy, A; COHERE in EuroCoord; ACHIeV2e Study Group (2017). CD4 cell count response to first-line combination ART in HIV-2+ patients compared with HIV-1+ patients: a multinational, multicohort European study. Journal of Antimicrobial Chemotherapy, 72:2869-2878. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2017 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Institute of Medical Virology, 570 Life sciences, biology, 610 Medicine & health |
| الوصف: | Background: CD4 cell recovery following first-line combination ART (cART) is poorer in HIV-2+ than in HIV-1+ patients. Only large comparisons may allow adjustments for demographic and pretreatment plasma viral load (pVL). Methods: ART-naive HIV+ adults from two European multicohort collaborations, COHERE (HIV-1 alone) and ACHIeV2e (HIV-2 alone), were included, if they started first-line cART (without NNRTIs or fusion inhibitors) between 1997 and 2011. Patients without at least one CD4 cell count before start of cART, without a pretreatment pVL and with missing a priori-defined covariables were excluded. Evolution of CD4 cell count was studied using adjusted linear mixed models. Results: We included 185 HIV-2+ and 30321 HIV-1+ patients with median age of 46 years (IQR 36–52) and 37 years (IQR 31–44), respectively. Median observed pretreatment CD4 cell counts/mm3 were 203 (95% CI 100–290) in HIV-2+ patients and 223 (95% CI 100–353) in HIV-1+ patients. Mean observed CD4 cell count changes from start of cART to 12 months were +105 (95% CI 77–134) in HIV-2+ patients and +202 (95% CI 199–205) in HIV-1+ patients, an observed difference of 97 cells/mm3 in 1 year. In adjusted analysis, the mean CD4 cell increase was overall 25 CD4 cells/mm3/year lower (95% CI 5–44; P = 0.0127) in HIV-2+ patients compared with HIV-1+ patients. Conclusions: A poorer CD4 cell increase during first-line cART was observed in HIV-2+ patients, even after adjusting for pretreatment pVL and other potential confounders. Our results underline the need to identify more potent therapeutic regimens or strategies against HIV-2. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0305-7453 |
| Relation: | https://www.zora.uzh.ch/id/eprint/145735/1/MS_COHERE_ACHIEV2E_revision2_JAC.pdf; info:pmid/29091198; urn:issn:0305-7453 |
| DOI: | 10.1093/jac/dkx210 |
| الاتاحة: | https://www.zora.uzh.ch/id/eprint/145735/ https://www.zora.uzh.ch/id/eprint/145735/1/MS_COHERE_ACHIEV2E_revision2_JAC.pdf https://doi.org/10.1093/jac/dkx210 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.668F532F |
| قاعدة البيانات: | BASE |
| تدمد: | 03057453 |
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| DOI: | 10.1093/jac/dkx210 |