Academic Journal
Pre-procedural predictive factors of symptomatic intracranial hemorrhage after thrombectomy in stroke.
| العنوان: | Pre-procedural predictive factors of symptomatic intracranial hemorrhage after thrombectomy in stroke. |
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| المؤلفون: | Venditti, L., Chassin, O., Ancelet, C., Legris, N., Sarov, M., Lapergue, B., Mihalea, C., Ozanne, A., Gallas, S., Cortese, J., Chalumeau, V., Ikka, L., Caroff, J., Labreuche, Julien, Spelle, L., Denier, C. |
| المساهمون: | Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris-Saclay, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille) |
| المصدر: | Journal of Neurology ; https://hal.univ-lille.fr/hal-04469998 ; Journal of Neurology, 2021, Journal of Neurology, 268, p. 1867-1875. ⟨10.1007/s00415-020-10364-x⟩ |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Ischemic stroke, Symptomatic intracranial hemorrhage, Predictive factors, Thrombectomy, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; ObjectiveSymptomatic intracerebral hemorrhage (sICH) is a common complication of acute ischemic stroke (AIS) associated with limited treatments and poor outcomes. We aimed to identify predictive factors of sICH in patients with AIS following mechanical thrombectomy (MT) in a real-world setting.MethodsPatients with large vessel occlusion of the anterior circulation treated with MT were consecutively included in a prospective monocentric cohort. Clinical, biological, and radiological parameters were collected to identify pre-procedural predictors for sICH.Results637 patients were included in our study. Magnetic resonance imaging was performed on most patients (86.7%). sICH occurred in 55 patients (8.6%). 428 patients (67.2%) were treated with intravenous thrombolysis. After multivariate analysis, prior use of antiplatelet therapies (odd ratio (OR) 1.84, 95% confidence interval (CI) 1.01–3.32), high C-reactive protein (OR per standard deviation (SD) increase 1.28, 95% 1.01–1.63), elevated mean arterial blood pressure (OR per 10 mmHg increase 1.22, 95% CI 1.03–1.44), hyperglycemia (OR per one SD-log increase 1.38, 95% CI 1.02–1.87), and low ASPECTS (OR per 1-point decrease 1.42, 95% CI 1.12–1.80) were found to be independent predictive factors of sICH. The pre-procedural predictors did not change when the absence of successful recanalization was considered as a covariate. Patients with strokes of unknown onset time were not especially vulnerable for sICH.ConclusionsICH after MT was associated with several pre-procedural risk factors: prior use of antiplatelet therapies, high C-reactive protein and hyperglycemia at baseline, elevated mean arterial blood pressure, and low ASPECTS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33389028; hal-04469998; https://hal.univ-lille.fr/hal-04469998; PUBMED: 33389028 |
| DOI: | 10.1007/s00415-020-10364-x |
| الاتاحة: | https://hal.univ-lille.fr/hal-04469998 https://doi.org/10.1007/s00415-020-10364-x |
| رقم الانضمام: | edsbas.66875D08 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00415-020-10364-x |
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