التفاصيل البيبلوغرافية
| العنوان: |
DHEA pre-treated patients, poor responders to a first IVF (ICSI) cycle: clinical results. |
| المؤلفون: |
Poli E, Manfè S, Capuzzo D, Gava S, Viganò F, CORONELLA, MARIA LIA, GANGEMI, MICHELE |
| المساهمون: |
Poli, E, Manfè, S, Capuzzo, D, Gava, S, Viganò, F, Coronella, MARIA LIA, Gangemi, Michele |
| سنة النشر: |
2014 |
| المجموعة: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| الوصف: |
Purpose: To evaluate the effect of the premedication with dehydroepiandrosterone (DHEA) on the results of the in vitro fertilization (IVF) treatments in a group of women with evidence of diminished ovarian reserve. Materials and Methods: This experimental, prospective, pre-post study enrolled 29 patients with evidence of diminished ovarian reserve and poor-responders to a previous treatment. They received 75 mg/die of DHEA for a minimum of eight weeks; from the 18th day of the cycle before the stimulation with follicle stimulating hormone (FSH), they took trans-dermal estradiol (E2) (50 mcg every other day). The protocol of the stimulation consisted of a short cycle with follicle stimulating hormone receptor-human menopausal gonadrotropin (FSHr-HMG) and low doses of gonadotropin releasing hormone agonist (GnRH-a) (0.05 mg/die). The study was carried out comparing the results obtained respectively with the pre-DHEA and the post-DHEA treatments. Results: The comparative analysis of the results showed a significant increase in the number of the retrieved oocytes (p < 0.01), of the oocyte quality (p = 0.02) and a reduction of cancelled cycles (p = 0.03). Moreover, after the treatment with DHEA, there was an increase, though non-significant, in the number of embryos, in the fertilization rate, and in the number of pregnancies. Conclusions: This study confirms the beneficial effects of DHEA in patients who resulted poor responders to IVF treatments. Therefore, DHEA appears to be an effective treatment for age related sub-fertility |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
STAMPA |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/24707673; info:eu-repo/semantics/altIdentifier/wos/WOS:000343848600001; volume:41; issue:1; firstpage:5; lastpage:9; numberofpages:5; journal:CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY; http://hdl.handle.net/11577/2892917; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84895821658 |
| الاتاحة: |
http://hdl.handle.net/11577/2892917 |
| رقم الانضمام: |
edsbas.668005F1 |
| قاعدة البيانات: |
BASE |