Enzyme‐Controlled Nanodevice for Acetylcholine‐Triggered Cargo Delivery Based on Janus Au–Mesoporous Silica Nanoparticles

التفاصيل البيبلوغرافية
العنوان:	Enzyme‐Controlled Nanodevice for Acetylcholine‐Triggered Cargo Delivery Based on Janus Au–Mesoporous Silica Nanoparticles
المؤلفون:	Llopis‐Lorente, Antoni, Díez, Paula, de la Torre, Cristina, Sánchez, Alfredo, Sancenón, Félix, Aznar, Elena, Marcos, María D., Martínez‐Ruíz, Paloma, Martínez‐Máñez, Ramón, Villalonga, Reynaldo
المساهمون:	Secretaría de Estado de Investigación, Desarrollo e Innovación, Generalitat Valenciana, Consejería de Educación, Juventud y Deporte, Comunidad de Madrid
المصدر:	Chemistry – A European Journal ; volume 23, issue 18, page 4276-4281 ; ISSN 0947-6539 1521-3765
بيانات النشر:	Wiley
سنة النشر:	2017
المجموعة:	Wiley Online Library (Open Access Articles via Crossref)
الوصف:	This work reports a new gated nanodevice for acetylcholine‐triggered cargo delivery. We prepared and characterized Janus Au–mesoporous silica nanoparticles functionalized with acetylcholinesterase on the Au face and with supramolecular β‐cyclodextrin:benzimidazole inclusion complexes as caps on the mesoporous silica face. The nanodevice is able to selectively deliver the cargo in the presence of acetylcholine via enzyme‐mediated acetylcholine hydrolysis, locally lowering the pH and opening the supramolecular gate. Given the key role played by ACh and its relation with Parkinson's disease and other nervous system diseases, we believe that these findings could help design new therapeutic strategies.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
DOI:	10.1002/chem.201700603
الاتاحة:	http://dx.doi.org/10.1002/chem.201700603 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.201700603 https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201700603
Rights:	http://onlinelibrary.wiley.com/termsAndConditions#vor
رقم الانضمام:	edsbas.665256B9
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1002/chem.201700603