Academic Journal
Clinical presentation of laboratory confirmed neurosyphilis in a recent cases series
| العنوان: | Clinical presentation of laboratory confirmed neurosyphilis in a recent cases series |
|---|---|
| المؤلفون: | Ouwens, Ingrid M. Daey, Ott, Alewijn, Fiolet, Aernoud, Koehler, Peter J., Vos, Martin, Oldhoff, J. Marja, Verhoeven, Willem M. A. |
| المصدر: | Ouwens , I M D , Ott , A , Fiolet , A , Koehler , P J , Vos , M , Oldhoff , J M & Verhoeven , W M A 2019 , ' Clinical presentation of laboratory confirmed neurosyphilis in a recent cases series ' , Clinical neuropsychiatry , vol. 16 , no. 1 , pp. 17-24 . < https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/34908934/ > |
| سنة النشر: | 2019 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | neurosyphilis, neuropsychiatry, treponema pallidum, syphilis, HIV co-infection, JARISCH-HERXHEIMER REACTION, CSF BARRIER FUNCTION, EPIDEMIC, PATIENT |
| الوصف: | Objective: The worldwide increase in the incidence of syphilis necessitates alertness to the occurrence of neurosyphilis. Early recognition of neurosyphilis allows for timely treatment, leading to a better treatment outcome. This retrospective study aims to describe the clinical presentation of neurosyphilis in a recent series of neurosyphilis patients. Method: All patients were included with a new, laboratory confirmed, diagnosis of neurosyphilis in the period 2004-2018. The clinical data were analysed. Results: 34 neurosyphilis patients (1 woman and 33 men) were identified. Age varied from 31-84 years (median age: 44 years). A history of syphilis infection was known for 11 (32%) patients; 12 (35%) patients were HIV seropositive. The distribution of the clinical syndromes was as follows: 16 patients with early neurosyphilis (acute meningitis, meningovasculitis and/or uveitis), 9 patients with late neurosyphilis (General Paralysis of the Insane and/or Tabes Dorsalis), 2 patients with symptoms of both early and late neurosyphilis, 6 patients with asymptomatic neurosyphilis and in 1 patient insufficient data were available to determine a clinical syndrome. Early neurosyphilis was seen in all age categories, late neurosyphilis only occurred in patients > 40 years. Conclusions: Neurosyphilis occurs in adults in all age groups, in men more frequent than in women, often in HIV-infected patients, and can present with a wide range of clinical syndromes. Usually no previous infection with syphilis is known. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الاتاحة: | https://hdl.handle.net/11370/d7607b3a-39ab-4e67-94ee-400e167f57af https://research.rug.nl/en/publications/d7607b3a-39ab-4e67-94ee-400e167f57af https://pure.rug.nl/ws/files/255727357/cn_16_017.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/34908934/ |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.66391B35 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |