التفاصيل البيبلوغرافية
| العنوان: |
Table_1_Lactobacillus casei Strain Shirota Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Increasing Taurine-Conjugated Bile Acids and Inhibiting NF-κB Signaling via Stabilization of IκBα.DOCX |
| المؤلفون: |
Wing-Yan Wong, Brandon Dow Chan, Tung-Ting Sham, Magnolia Muk-Lan Lee, Chi-On Chan, Chung-Ting Chau, Daniel Kam-Wah Mok, Yiu-Wa Kwan, William Chi-Shing Tai |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Clinical and Sports Nutrition, Dietetics and Nutrigenomics, Nutritional Physiology, Public Nutrition Intervention, Nutrition and Dietetics not elsewhere classified, Food Chemistry and Molecular Gastronomy (excl. Wine), Food Nutritional Balance, Animal Nutrition, Crop and Pasture Nutrition, probiotics, inflammatory bowel disease, Lactobacillus casei strain Shirota, gut microbiota, bile acids, DSS-induced acute colitis |
| الوصف: |
Inflammatory bowel disease (IBD) is a chronic progressive intestinal inflammatory disease, characterized by an altered gut microbiota composition and accompanying alterations in circulatory bile acids. Increasing evidence supports the beneficial effect of probiotics intake on health. Introduction of probiotics to the intestines can modulate gut microbiota composition and in turn regulate the host immune system and modify the inflammatory response. Probiotics can also improve intestinal barrier function and exhibit a positive impact on host physiological and pathological conditions via gut microbiota-derived metabolites. Previous studies have demonstrated that Lactobacillus casei strain Shirota (LcS) treatment could inhibit clinical manifestation of colitis in dextran sulfate sodium (DSS)-induced mice, however, the underlying mechanisms remain unknown. In this study, we employed the DSS-induced acute colitis mouse model to investigate the anti-inflammatory effects of LcS and related mechanisms. Administration of LcS ameliorated the severity of DSS-induced colitis and enhanced intestinal integrity via induction of mucin-2 and occludin expression in colons. Fecal microbiota analysis showed that LcS increased the relative abundance of beneficial bacterial species in colitic mice, whereas the relative abundance of pathobionts was reduced. Additionally, LcS treatment modulated circulating bile acid profiles in colitic mice. In mice treated with LcS, we identified increased levels of primary taurine-conjugated bile acids, including taurocholic acid (TCA) and taurochenodeoxycholic acid (TCDCA). LcS treatment also increased the levels of secondary taurine-conjugated bile acids, including taurodeoxycholic acid (TDCA) and tauroursodeoxycholic acid (TUDCA). Moreover, LcS treatment exhibited a suppressive effect on the hydroxylated primary bile acids α-muricholic acid (α-MCA) and β-muricholic acid (β-MCA). We further demonstrated that LcS treatment suppressed the expression of pro-inflammatory mediators interferon-gamma ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Table_1_Lactobacillus_casei_Strain_Shirota_Ameliorates_Dextran_Sulfate_Sodium-Induced_Colitis_in_Mice_by_Increasing_Taurine-Conjugated_Bile_Acids_and_Inhibiting_NF-_B_Signaling_via_Stabilization_of_I_B_DOCX/19625007 |
| DOI: |
10.3389/fnut.2022.816836.s001 |
| الاتاحة: |
https://doi.org/10.3389/fnut.2022.816836.s001
https://figshare.com/articles/dataset/Table_1_Lactobacillus_casei_Strain_Shirota_Ameliorates_Dextran_Sulfate_Sodium-Induced_Colitis_in_Mice_by_Increasing_Taurine-Conjugated_Bile_Acids_and_Inhibiting_NF-_B_Signaling_via_Stabilization_of_I_B_DOCX/19625007 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.66018DAB |
| قاعدة البيانات: |
BASE |