Academic Journal
In utero arsenic exposure is associated with impaired thymic function in newborns possibly via oxidative stress and apoptosis
| العنوان: | In utero arsenic exposure is associated with impaired thymic function in newborns possibly via oxidative stress and apoptosis |
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| المؤلفون: | Ahmed, Sultan, Ahsan, Khalid Bin, Kippler, Maria, Mily, Akhirunnesa, Wagatsuma, Yukiko, Hoque, A.M. Waheedul, Ngom, Pa Tamba, Arifeen, Shams El, Raqib, Rubhana, Vahter, Marie |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2012 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Research Article |
| الوصف: | Prenatal arsenic exposure is associated with increased infant morbidity and reduced thymus size, indicating arsenic-related developmental immunotoxicity. We aimed to evaluate effects of prenatal arsenic exposure on thymic function at birth, and related mechanisms of action. In a Bangladeshi cohort, arsenic was measured in urine (U-As, gestational week (GW) 8 and 30) and blood (B-As, GW14) in 130 women. Child thymic index was measured by sonography at birth and thymic function by signal-joint T cell receptor-rearrangement excision circles (sjTRECs) in cord blood mononuclear cells (CBMC). In a sub-sample (n=44), sjTRECs content in isolated CD4+ and CD8+ T cells, expression of oxidative-stress defense and apoptosis-related genes in CBMC, arsenic concentrations (urine, placenta and cord blood), and oxidative stress markers in placenta and cord blood were measured. In multivariable-adjusted regression, ln U-As (GW8) was inversely associated with ln sjTRECs in CBMC (B=-0.25; 95% CI -0.48, -0.01). Using multivariable-adjusted spline regression, ln U-As (GW30) and ln B-As (GW14) were inversely associated with ln sjTRECs in CBMC (B=-0.53; 95% CI -0.93, -0.13 and B=-1.27; 95% CI -1.89, -0.66, respectively) below spline knots at U-As 150 µg/L and B-As 6 µg/kg. Similar inverse associations were observed in separated CD4+ and CD8+ T cells. Arsenic was positively associated with 8-hydroxy-2'-deoxyguanosine in cord blood (B=0.097; 95% CI 0.05, 0.13), which was inversely associated with sjTRECs in CD4+ and CD8+ T cells. In conclusion, prenatal arsenic exposure was associated with reduced thymic function, possibly via induction of oxidative stress and apoptosis, suggesting subsequent immunosuppression in childhood. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://toxsci.oxfordjournals.org/cgi/content/short/kfs202v1; http://dx.doi.org/10.1093/toxsci/kfs202 |
| DOI: | 10.1093/toxsci/kfs202 |
| الاتاحة: | http://toxsci.oxfordjournals.org/cgi/content/short/kfs202v1 https://doi.org/10.1093/toxsci/kfs202 |
| Rights: | Copyright (C) 2012, Society of Toxicology |
| رقم الانضمام: | edsbas.65F70DA6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/toxsci/kfs202 |
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