Academic Journal
Intercomparison of radiosensitization induced by gold and iron oxide nanoparticles in human glioblastoma cells irradiated by 6 MV photons
| العنوان: | Intercomparison of radiosensitization induced by gold and iron oxide nanoparticles in human glioblastoma cells irradiated by 6 MV photons |
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| المؤلفون: | Guerra, Danieli B., Oliveira, Elisa M. N., Sonntag, Amanda R., Sbaraine, Patricia, Fay, Andre P., Morrone, Fernanda B., Papaléo, Ricardo M. |
| المساهمون: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Instituto Nacional de Ciência e Tecnologia para Engenharia de Software, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul |
| المصدر: | Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| الوصف: | In this work, an intercomparison of sensitization effects produced by gold (GNP) and dextran-coated iron oxide (SPION-DX) nanoparticles in M059J and U87 human glioblastoma cells was performed using 6 MV-photons. Three variables were mapped: the nanoparticle material, treatment concentration, and cell radiosensitivity. For U87, GNP treatments resulted in high sensitization enhancement ratios (SER $$_{10\%}$$ 10 % up to 2.04). More modest effects were induced by SPION-DX, but still significant reductions in survival were achieved (maximum SER $$_{10\%}=1.61$$ 10 % = 1.61 ). For the radiosensitive M059J, sensitization by both NPs was poor. SER $$_{10\%}$$ 10 % increased with the degree of elemental uptake in the cells, but not necessarily with treatment concentration. For GNP, where exposure concentration and elemental uptake were found to be proportional, SER $$_{10\%}$$ 10 % increased linearly with concentration in both cell lines. For SPION-DX, saturation of sensitization enhancement and metal uptake occurred at high exposures. Fold change in the $$\alpha /\beta$$ α / β ratios extracted from survival curves are reduced by the presence of SPION-DX but strongly increased by GNPs , suggesting that sensitization by GNPs occurs mainly via promotion of lethal damage, while for SPION-DX repairable damage dominates. The NPs were more effective in eliminating the radioresistant glioblastoma cells, an interesting finding, as resistant cells are key targets to improve treatment outcome. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-022-13368-x |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-022-13368-x https://www.nature.com/articles/s41598-022-13368-x.pdf https://www.nature.com/articles/s41598-022-13368-x |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.65D408B5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-022-13368-x |
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