Academic Journal
The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis
| العنوان: | The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis |
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| المؤلفون: | Chang, Che-Chang, Huang, Yen-Sung, Lin, Ying-Mei, Lin, Chia-Ju, Jeng, Jen-Chong, Liu, Shin-Mei, Ho, Tsai-Ling, Chang, Ruei-Ting, Changou, Chun A., Ho, Chun-Chen, Shih, Hsiu-Ming |
| المساهمون: | Ministry of Science and Technology, Taiwan |
| المصدر: | Scientific Reports ; volume 8, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2018 |
| الوصف: | Smad4, a common-mediator of Smads, plays a central role in forming complexes with receptor-phosphorylated Smads, and then transduces transforming growth factor (TGF)-β signals into the nuclei. Although many cellular factors are involved in TGF-β induced epithelial-to-mesenchymal transition (EMT) and cell migration, very little is known with the mechanism of Smad4 regulation on pro-oncogenes response by TGF-β. Herein, we demonstrate the interaction of Sentrin-specific protease 2 (SENP2) with Smad4 through SENP2 residue 363~400. The same segment is also important for desumoylation of Smad4, and able to relieve sumoylation-mediated TGF-β repression. The SENP2 363~400 segment is critical for TGF-β-induced cell migration, which is correlated with SENP2 363~400 deletion mutant failed to increase matrix metalloproteinase (MMP)-9 and EMT marker gene expression. Moreover, our results suggest that the interaction and desumoylation between SENP2 and Smad4 promote cell migration in triple-negative breast cancer cells. Altogether, our data show how SENP2 regulates its substrate for desumoylation, and also the role of SENP2 in TGF-β induced cancer cell migration. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-018-28103-8 |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-018-28103-8 https://www.nature.com/articles/s41598-018-28103-8.pdf https://www.nature.com/articles/s41598-018-28103-8 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.65C071BB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-018-28103-8 |
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