Academic Journal
Differential antinociceptive effect of transcutaneous electrical stimulation on pain behavior sensitive or insensitive to phentolamine in neuropathic rats
| العنوان: | Differential antinociceptive effect of transcutaneous electrical stimulation on pain behavior sensitive or insensitive to phentolamine in neuropathic rats |
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| المساهمون: | Taick Sang Nam, Yoon Choi, Dong Soo Yeon, Joong Woo Leem, Kwang Se Paik, Nam, Taick Sang, Leem, Joong Woo |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Adrenergic alpha-Antagonists/pharmacology, Animals, Cold Temperature, Hindlimb/drug effects, Hyperalgesia/therapy, Male, Pain Measurement/drug effects, Pain Measurement/methods, Peripheral Nervous System Diseases/therapy, Phentolamine/pharmacology, Rats, Sprague-Dawley, Spinal Nerves/injuries, Touch, Transcutaneous Electric Nerve Stimulation, Neuropathic pain, Electrical stimulation, Mechanical allodynia, Cold hyperalgesia, Naloxone, Sympathetic dependency |
| الوصف: | The effects of transcutaneous electrical stimulation and systemic injection of phentolamine, a non-specific alpha-adrenergic antagonist, on the behavioral signs of mechanical allodynia and cold hyperalgesia in rats with nerve injury were investigated. Mechanical allodynia and cold hyperalgesia were evaluated by measuring the paw withdrawal frequency (PWF) resulting from repetitive application of a von Frey hair and the paw lift duration (PLD) at a cold temperature, respectively. After a unilateral nerve injury, both PWF and PLD increased in the injured hind paw. Application of low-frequency, high-intensity transcutaneous electrical stimulation (LFHI-TES) to the injured hind paw depressed the injury-induced increased PWF, whereas it had no effect on the injury-induced increased PLD. Naloxone reversed the LFHI-TES produced depression of PWF. Intraperitoneal administration of phentolamine depressed the injury-induced increased PLD without affecting the injury-induced increased PWF. Our results suggest that LFHI-TES, which activates the endogenous opioid systems, produces an antinociceptive effect that appears to be related to whether or not the pain is mediated by sympathetic activity. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 17~20 |
| اللغة: | unknown |
| تدمد: | 0304-3940 1872-7972 |
| Relation: | NEUROSCIENCE LETTERS; J02364; OAK-2001-00808; https://ir.ymlib.yonsei.ac.kr/handle/22282913/142688; http://www.sciencedirect.com/science/article/pii/S0304394001015877; T200102808; NEUROSCIENCE LETTERS, Vol.301(1) : 17-20, 2001 |
| DOI: | 10.1016/S0304-3940(01)01587-7 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142688 https://doi.org/10.1016/S0304-3940(01)01587-7 http://www.sciencedirect.com/science/article/pii/S0304394001015877 |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ ; not free |
| رقم الانضمام: | edsbas.65933DEB |
| قاعدة البيانات: | BASE |
| تدمد: | 03043940 18727972 |
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| DOI: | 10.1016/S0304-3940(01)01587-7 |