التفاصيل البيبلوغرافية
| العنوان: |
Differential Immune Checkpoint and Ig-like V-Type Receptor Profiles in COVID-19: Associations with Severity and Treatment |
| المؤلفون: |
Roberto Lozano-Rodríguez, Verónica Terrón-Arcos, Raúl López, Juan Martín-Gutiérrez, Alejandro Martín-Quirós, Charbel Maroun-Eid, Elena Muñoz del Val, Carlos Cañada-Illana, Alejandro Pascual Iglesias, Jaime Valentín Quiroga, Karla Montalbán-Hernández, José Carlos Casalvilla-Dueñas, Miguel A. García-Garrido, Álvaro del Balzo-Castillo, María A. Peinado-Quesada, Laura Gómez-Lage, Carmen Herrero-Benito, Ray G. Butler, José Avendaño-Ortiz, Eduardo López-Collazo |
| المصدر: |
Journal of Clinical Medicine; Volume 11; Issue 12; Pages: 3287 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
COVID-19, immune phenotype, immune-checkpoints, Ig-like V-type receptors, secondary infections, corticosteroids |
| الوصف: |
Identifying patients’ immune system status has become critical to managing SARS-CoV-2 infection and avoiding the appearance of secondary infections during a hospital stay. Despite the high volume of research, robust severity and outcome markers are still lacking in COVID-19. We recruited 87 COVID-19 patients and analyzed, by unbiased automated software, 356 parameters at baseline emergency department admission including: high depth immune phenotyping and immune checkpoint expression by spectral flow cytometry, cytokines and other soluble molecules in plasma as well as routine clinical variables. We identified 69 baseline alterations in the expression of immune checkpoints, Ig-like V type receptors and other immune population markers associated with severity (O2 requirement). Thirty-four changes in these markers/populations were associated with secondary infection appearance. In addition, through a longitudinal sample collection, we described the changes which take place in the immune system of COVID-19 patients during secondary infections and in response to corticosteroid treatment. Our study provides information about immune checkpoint molecules and other less-studied receptors with Ig-like V-type domains such as CD108, CD226, HVEM (CD270), B7H3 (CD276), B7H5 (VISTA) and GITR (CD357), defining these as novel interesting molecules in severe and corticosteroids-treated acute infections. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Infectious Diseases; https://dx.doi.org/10.3390/jcm11123287 |
| DOI: |
10.3390/jcm11123287 |
| الاتاحة: |
https://doi.org/10.3390/jcm11123287 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.655546AA |
| قاعدة البيانات: |
BASE |