Academic Journal
IGLR-2, a Leucine-Rich Repeat Domain Containing Protein, Is Required for the Host Defense in Caenorhabditis elegans
| العنوان: | IGLR-2, a Leucine-Rich Repeat Domain Containing Protein, Is Required for the Host Defense in Caenorhabditis elegans |
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| المؤلفون: | Kuo, Cheng-Ju, Hsu, Ya-Chu, Wang, Sin-Tian, Liou, Bang-Yu, Lim, Serene Boon-Yuean, Chen, Yi-Wei, Chen, Chang-Shi |
| المساهمون: | Ministry of Science and Technology |
| المصدر: | Frontiers in Immunology ; volume 11 ; ISSN 1664-3224 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2020 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Enterohemorrhagic Escherichia coli (EHEC), a human pathogen, also infects Caenorhabditis elegans . We demonstrated previously that C. elegans activates the p38 MAPK innate immune pathway to defend against EHEC infection. However, whether a C. elegans pattern recognition receptor (PRR) exists to regulate the immune pathway remains unknown. PRRs identified in other metazoans contain several conserved domains, including the leucine-rich repeat (LRR). By screening a focused RNAi library, we identified the IGLR-2, a transmembrane protein containing the LRR domain, as a potential immune regulator in C. elegans . Our data showed that iglr-2 regulates the host susceptibility to EHEC infection. Moreover, iglr-2 is required for pathogen avoidance to EHEC. The iglr-2 overexpressed strain, which was more resistant to EHEC originally, showed hypersusceptibility to EHEC upon knockdown of the p38 MAPK pathway. Together, our data suggested that iglr-2 plays an important role in C. elegans to defend EHEC by regulating pathogen-avoidance behavior and the p38 MAPK pathway. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fimmu.2020.561337 |
| DOI: | 10.3389/fimmu.2020.561337/full |
| الاتاحة: | http://dx.doi.org/10.3389/fimmu.2020.561337 https://www.frontiersin.org/articles/10.3389/fimmu.2020.561337/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.653BE72 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2020.561337 |
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