Academic Journal
The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model
| العنوان: | The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model |
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| المؤلفون: | Telerman, Alona, Kashman, Yoel, Ofir, Rivka, Elmann, Anat |
| المصدر: | Israel Journal of Plant Sciences ; volume 68, issue 1-2, page 107-114 ; ISSN 0792-9978 2223-8980 |
| بيانات النشر: | Brill |
| سنة النشر: | 2021 |
| الوصف: | Plant-derived substances have been shown to affect potential targets in inflammatory diseases. We have previously purified from the desert plant Achillea fragrantissima , a sesquiterpene lactone named achillolide A, and demonstrated its anti-inflammatory activities in cultured brain macrophages named microglial cells. In the present study, we further investigated achillolide A in alleviating atopic dermatitis, a chronic and recurring inflammatory skin disease. We investigated achillolide A for its in vivo anti-inflammatory activity using the oxazolone model of atopic dermatitis in mice, in which oxazolone induces ear swelling. Our results show that mice treated with achillolide A showed a significant decrease in the oxazolone-induced ear swelling. Since macrophages are inflammatory cells that play a pivotal role in the pathogenesis of atopic dermatitis, the anti-inflammatory effects of achillolide A were also studied in spleen cells. We demonstrated that achillolide A reduced the levels of LPS-induced inflammatory cytokines IL-2, IL-6, TNFα, IFNγ and IL-12 that were secreted from cultured splenocytes. These data suggest that achillolide A should be considered for further research in treating atopic dermatitis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.1163/22238980-bja10035 |
| الاتاحة: | http://dx.doi.org/10.1163/22238980-bja10035 https://brill.com/view/journals/ijps/68/1-2/article-p107_107.xml https://brill.com/downloadpdf/journals/ijps/68/1-2/article-p107_107.xml |
| رقم الانضمام: | edsbas.6532024F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1163/22238980-bja10035 |
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