Academic Journal
In vivo dynamic imaging, in silico modeling and global sensitivity analysis for the study and the diagnosis of epithelial neoplasia
| العنوان: | In vivo dynamic imaging, in silico modeling and global sensitivity analysis for the study and the diagnosis of epithelial neoplasia |
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| المؤلفون: | Μπαλας Κωστας(http://users.isc.tuc.gr/~cbalas), Balas Costas(http://users.isc.tuc.gr/~cbalas), Παπουτσογλου Γεωργιος(http://users.isc.tuc.gr/~gpapoutsoglou), Papoutsoglou Georgios(http://users.isc.tuc.gr/~gpapoutsoglou), Αναστασοπουλου Αγγελικη(http://users.isc.tuc.gr/~aanastasopoulou1), Anastasopoulou Angeliki(http://users.isc.tuc.gr/~aanastasopoulou1), Σταυρακακης Γεωργιος(http://users.isc.tuc.gr/~gstavrakakis), Stavrakakis Georgios(http://users.isc.tuc.gr/~gstavrakakis), W.P. Soutter() |
| بيانات النشر: | Institute of Electrical and Electronics Engineers |
| سنة النشر: | 2015 |
| المجموعة: | Technical University of Crete: Institutional Repository / Πολυτεχνείο Κρήτης: Ιδρυματικό Αποθετήριο |
| الوصف: | Summarization: We present a method for detecting and studying neoplasia-specific functional and structural features through the combination of in vivo dynamic imaging, in silico modeling and global sensitivity analysis. We particularly present the case of cervical epithelium interacting with acetic acid solution, which is employed as an optical biomarker. The in vivo measured dynamic scattering characteristics are strongly correlated with the output of the biomarker's pharmacokinetic model that we have developed. Model global sensitivity analysis has shown that the measured/modeled bio-optical processes can be used for probing, in vivo, the number of neoplastic layers, the extracellular pH, the intracellular buffering efficiency and the size of the extracellular space. ; Παρουσιάστηκε στο: Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/grantAgreement/EC/FP7/246686; http://purl.tuc.gr/dl/dias/B30F7A58-E40E-45D7-A508-C1EC4C018543 |
| DOI: | 10.1109/IEMBS.2011.6089905 |
| الاتاحة: | http://purl.tuc.gr/dl/dias/B30F7A58-E40E-45D7-A508-C1EC4C018543 https://doi.org/10.1109/IEMBS.2011.6089905 |
| Rights: | info:eu-repo/semantics/openAccess ; Όροι χρήσης: Μη διαθέσιμο ; License: http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.650FD036 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1109/IEMBS.2011.6089905 |
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