التفاصيل البيبلوغرافية
| العنوان: |
Catheter-based intramyocardial injection of FGF1 or NRG1-loaded MPs improves cardiac function in a preclinical model of ischemia-reperfusion |
| المؤلفون: |
Garbayo, E, Gavira, J.J. (Juan José), Garcia-de-Yebenes, M. (Manuel), Pelacho, B. (Beatriz), Abizanda-Sarasa, G. (Gloria), Lana, H. (Hugo), Blanco-Prieto, M.J. (María José), Prosper-Cardoso, F. (Felipe) |
| بيانات النشر: |
Nature Publishing Group |
| سنة النشر: |
2016 |
| المجموعة: |
dadun - Depósito Académico Digital Universidad de Navarra |
| مصطلحات موضوعية: |
Catheter-based intramyocardial Injection, Cardiac function, Ischemia- reperfusion, Neuregulin (NRG1), Acidic-fibroblast growth factor (FGF1), Materias Investigacion::Farmacia::Tecnología farmacéutica |
| الوصف: |
Cardiovascular protein therapeutics such as neuregulin (NRG1) and acidic-fibroblast growth factor (FGF1) requires new formulation strategies that allow for sustained bioavailability of the drug in the infarcted myocardium. However, there is no FDA-approved injectable protein delivery platform due to translational concerns about biomaterial administration through cardiac catheters. We therefore sought to evaluate the efficacy of percutaneous intramyocardial injection of poly(lactic-co-glycolic acid) microparticles (MPs) loaded with NRG1 and FGF1 using the NOGA MYOSTAR injection catheter in a porcine model of ischemia-reperfusion. NRG1- and FGF1-loaded MPs were prepared using a multiple emulsion solvent-evaporation technique. Infarcted pigs were treated one week after ischemiareperfusion with MPs containing NRG1, FGF1 or non-loaded MPs delivered via clinically-translatable percutaneous transendocardial-injection. Three months post-treatment, echocardiography indicated a significant improvement in systolic and diastolic cardiac function. Moreover, improvement in bipolar voltage and decrease in transmural infarct progression was demonstrated by electromechanical NOGA-mapping. Functional benefit was associated with an increase in myocardial vascularization and remodeling. These findings in a large animal model of ischemia-reperfusion demonstrate the feasibility and efficacy of using MPs as a delivery system for growth factors and provide strong evidence to move forward with clinical studies using therapeutic proteins combined with catheter-compatible biomaterials. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://hdl.handle.net/10171/41316 |
| الاتاحة: |
https://hdl.handle.net/10171/41316 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.650036C7 |
| قاعدة البيانات: |
BASE |