Academic Journal
Widespread Recombination in Published Animal mtDNA Sequences
| العنوان: | Widespread Recombination in Published Animal mtDNA Sequences |
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| المؤلفون: | Tsaousis, A. D., Martin, D. P., Ladoukakis, E. D., Posada, D., Zouros, E. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2005 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Research Article |
| الوصف: | Mitochondrial DNA (mtDNA) recombination has been observed in several animal species, but there are doubts as to whether it is common or only occurs under special circumstances. Animal mtDNA sequences retrieved from public databases were unambiguously aligned and rigorously tested for evidence of recombination. At least 30 recombination events were detected among 186 alignments examined. Recombinant sequences were found in invertebrates and vertebrates, including primates. It appears that mtDNA recombination may occur regularly in the animal cell but rarely produces new haplotypes because of homoplasmy. Common animal mtDNA recombination would necessitate a re-examination of phylogenetic and biohistorical inference based on the assumption of clonal mtDNA transmission. Recombination may also have an important role in producing and purging mtDNA mutations and thus in mtDNA-based diseases and senescence. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://mbe.oxfordjournals.org/cgi/content/short/msi084v1; http://dx.doi.org/10.1093/molbev/msi084 |
| DOI: | 10.1093/molbev/msi084 |
| الاتاحة: | http://mbe.oxfordjournals.org/cgi/content/short/msi084v1 https://doi.org/10.1093/molbev/msi084 |
| Rights: | Copyright (C) 2005, Society for Molecular Biology and Evolution |
| رقم الانضمام: | edsbas.64DFAF9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/molbev/msi084 |
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