التفاصيل البيبلوغرافية
| العنوان: |
Enhanced Photothermal Performance by Carbon Dot-Chelated Polydopamine Nanoparticles |
| المؤلفون: |
Qingfeng Shu (11655185), Jie Liu (15128), Qing Chang (93814), Chenghao Liu (761535), Haifang Wang (67779), Yijun Xie (1793497), Xiaoyong Deng (8862206) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Pharmacology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, cancer cells compared, chelating carbon dots, carbon quantum dots, remarkable therapeutic performance, enhanced photothermal performance, responsive drug release, pure pda nanoparticles, cqds could also, photothermal therapy due, loading dox owing, responsive photothermal, photothermal therapy, carbon dot, therapeutic experiment, loading 60, drug carrier, photothermal efficiency, chemo therapy, wideband absorption, vitro <, uv protection, synergistic effect, still increased, radical scavenging, ph 5 |
| الوصف: |
Polydopamine (PDA) has been widely used in biomedical applications including imaging contrast agents, antioxidants, UV protection, and photothermal therapy due to its biocompatibility, metal-ion chelation, free-radical scavenging, and wideband absorption, but its low photothermal efficiency still needs to be improved. In this study, we chelated near-infrared (NIR) sensitive carbon quantum dots on the surface of polydopamine (PDA-PEI@N,S-CQDs) to increase its near-infrared absorption. Surprisingly, although only 4% (w/w) of carbon quantum dots was conjugated on the PDA surface, it still increased the photothermal efficiency by 30%. Moreover, PDA-PEI@N,S-CQDs could also be used as the drug carrier for loading 60% (w/w) of the DOX and achieved stimuli-responsive drug release under lysosomal pH (pH 5.0) and 808 nm laser illumination. For in vitro therapeutic experiment, PDA-PEI@N,S-CQDs showed the remarkable therapeutic performance under 808 nm laser irradiation for killing 90% of cancer cells compared with 50% by pure PDA nanoparticles, and the efficacy was even higher after loading DOX owing to the synergistic effect by photothermal therapy and chemotherapy. This intelligent and effective therapeutic nanosystem based on PDA-PEI@N,S-CQDs showed enhanced photothermal behavior after chelating carbon dots and promoted the future development of a nanoplatform for stimuli-responsive photothermal/chemo therapy. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Enhanced_Photothermal_Performance_by_Carbon_Dot-Chelated_Polydopamine_Nanoparticles/16942922 |
| DOI: |
10.1021/acsbiomaterials.1c01045.s001 |
| الاتاحة: |
https://doi.org/10.1021/acsbiomaterials.1c01045.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.64AFB0DE |
| قاعدة البيانات: |
BASE |