Academic Journal
Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling
| العنوان: | Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling |
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| المؤلفون: | Hauffe, Robert (Dr.), Rath, Michaela (Msc.), Agyapong, Wilson (Msc.), Jonas, Wenke (Dr.), Vogel, Heike (Dr.), Schulz, Tim Julius (Prof. Dr.), Schwarz, Maria (Dr.), Kipp, Anna Patricia (Dr.), Blüher, Matthias (Dr.), Kleinridders, André (Prof. Dr.) |
| المساهمون: | Ojeda Murillo, María Luisa, Nogales Bueno, Fátima |
| سنة النشر: | 2022 |
| المجموعة: | University of Potsdam: publish.UP |
| مصطلحات موضوعية: | ddc:610, Institut für Ernährungswissenschaft |
| الوصف: | The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium, as a crucial part of antioxidative selenoproteins, can protect against the development of diet-induced insulin resistance in white adipose tissue (WAT) by increasing glutathione peroxidase 3 (GPx3) and insulin receptor (IR) expression. Whether selenite (Se) can attenuate insulin resistance in established lipotoxic and obese conditions is unclear. We confirm that GPX3 mRNA expression in adipose tissue correlates with BMI in humans. Cultivating 3T3-L1 pre-adipocytes in palmitate-containing medium followed by Se treatment attenuates insulin resistance with enhanced GPx3 and IR expression and adipocyte differentiation. However, feeding obese mice a selenium-enriched high-fat diet (SRHFD) only resulted in a modest increase in overall selenoprotein gene expression in WAT in mice with unaltered body weight development, glucose tolerance, and insulin resistance. While Se supplementation improved adipocyte morphology, it did not alter WAT insulin sensitivity. However, mice fed a SRHFD exhibited increased insulin content in the pancreas. Overall, while selenite protects against palmitate-induced insulin resistance in vitro, obesity impedes the effect of selenite on insulin action and adipose tissue metabolism in vivo. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://publishup.uni-potsdam.de/frontdoor/index/index/docId/56170; urn:nbn:de:kobv:517-opus4-561709; https://nbn-resolving.org/urn:nbn:de:kobv:517-opus4-561709; https://doi.org/10.25932/publishup-56170; https://publishup.uni-potsdam.de/files/56170/pmnr1267.pdf |
| DOI: | 10.25932/publishup-56170 |
| الاتاحة: | https://publishup.uni-potsdam.de/frontdoor/index/index/docId/56170 https://nbn-resolving.org/urn:nbn:de:kobv:517-opus4-561709 https://doi.org/10.25932/publishup-56170 https://publishup.uni-potsdam.de/files/56170/pmnr1267.pdf |
| Rights: | https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.64879A8F |
| قاعدة البيانات: | BASE |
| DOI: | 10.25932/publishup-56170 |
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