Academic Journal
Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS?
| العنوان: | Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS? |
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| المؤلفون: | Alarcan, Hugo, Al Ojaimi, Yara, Lanznaster, Debora, Escoffre, Jean-Michel, Corcia, Philippe, Vourc’h, Patrick, Andres, Christian, R, Veyrat-Durebex, Charlotte, Blasco, Hélène |
| المساهمون: | Imaging, Brain & Neuropsychiatry (iBraiN), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours) |
| المصدر: | ISSN: 2075-4426 ; Journal of Personalized Medicine ; https://inserm.hal.science/inserm-03723283 ; Journal of Personalized Medicine, 2022, 12, pp.1071. ⟨10.3390/jpm12071071⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2022 |
| المجموعة: | Université François-Rabelais de Tours: HAL |
| مصطلحات موضوعية: | blood spinal cord barrier, amyotrophic lateral sclerosis, drug design, Blood-brain barrier BBB, [SCCO.NEUR]Cognitive science/Neuroscience |
| الوصف: | International audience ; Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that still lacks an efficient therapy. The barriers between the central nervous system (CNS) and the blood represent a major limiting factor to the development of drugs for CNS diseases, including ALS. Alterations of the blood–brain barrier (BBB) or blood–spinal cord barrier (BSCB) have been reported in this disease but still require further investigations. Interestingly, these alterations might be involved in the complex etiology and pathogenesis of ALS. Moreover, they can have potential consequences on the diffusion of candidate drugs across the brain. The development of techniques to bypass these barriers is continuously evolving and might open the door for personalized medical approaches. Therefore, identifying robust and non-invasive markers of BBB and BSCB alterations can help distinguish different subgroups of patients, such as those in whom barrier disruption can negatively affect the delivery of drugs to their CNS targets. The restoration of CNS barriers using innovative therapies could consequently present the advantage of both alleviating the disease progression and optimizing the safety and efficiency of ALS-specific therapies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | inserm-03723283; https://inserm.hal.science/inserm-03723283; https://inserm.hal.science/inserm-03723283/document; https://inserm.hal.science/inserm-03723283/file/jpm-12-01071-v2.pdf |
| DOI: | 10.3390/jpm12071071 |
| الاتاحة: | https://inserm.hal.science/inserm-03723283 https://inserm.hal.science/inserm-03723283/document https://inserm.hal.science/inserm-03723283/file/jpm-12-01071-v2.pdf https://doi.org/10.3390/jpm12071071 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.6484EC4F |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/jpm12071071 |
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