Academic Journal
Claustrum damage and refractory status epilepticus following febrile illness
| العنوان: | Claustrum damage and refractory status epilepticus following febrile illness |
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| المؤلفون: | MELETTI, Stefano, MONTI, Giulia, GIOVANNINI, GIADA, Slonkova, Jana, Mareckova, Iva, Specchio, Nicola, Hon, Petr, Marcian, Vaclav, Chiari, Annalisa, Krupa, Petr, Pietrafusa, Nicola, Berankova, Dagmar, Bar, Michal |
| المساهمون: | Meletti, Stefano, Slonkova, Jana, Mareckova, Iva, Monti, Giulia, Specchio, Nicola, Hon, Petr, Giovannini, Giada, Marcian, Vaclav, Chiari, Annalisa, Krupa, Petr, Pietrafusa, Nicola, Berankova, Dagmar, Bar, Michal |
| سنة النشر: | 2015 |
| المجموعة: | Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
| مصطلحات موضوعية: | EPILEPSY, STATUS EPILEPTICUS, CLAUSTRUM, NORSE |
| الوصف: | BACKGROUND: To characterize the clinical, EEG, and brain imaging findings in an adult case series of patients with de novo refractory status epilepticus (SE) occurring after a febrile illness. METHODS: A retrospective study (2010-2013) was undertaken with the following inclusion criteria: (1) previously healthy adults with refractory SE; (2) seizure onset 0-21 days after a febrile illness; (3) lacking evidence of infectious agents in CSF; (4) no history of seizures (febrile or afebrile) or previous or concomitant neurologic disorder. RESULTS: Among 155 refractory SE cases observed in the study period, 6 patients (17-35 years old) fulfilled the inclusion criteria. Confusion and stupor were the most common symptoms at disease onset, followed after a few days by acute repeated seizures that were uncountable in all but one. Seizures consisted of focal motor/myoclonic phenomena with subsequent generalization. Antiepileptic drugs failed in every patient to control seizures, with all participants requiring intensive care unit admission. Barbiturate coma with burst-suppression pattern was applied in 4 out of 6 patients for 5-14 days. One participant died in the acute phase. In each patient, we observed a reversible bilateral claustrum MRI hyperintensity on T2-weighted sequences, without restricted diffusion, time-related with SE. All patients had negative multiple neural antibodies testing. Four out of 5 surviving patients developed chronic epilepsy. CONCLUSIONS: This is a hypothesis-generating study of a preliminary nature supporting the role of the claustrum in postfebrile de novo SE; future prospective studies are needed to delineate the specificity of this condition, its pathogenesis, and the etiology. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/26341869; info:eu-repo/semantics/altIdentifier/wos/WOS:000362203200001; volume:85; issue:14; firstpage:1224; lastpage:1232; numberofpages:9; journal:NEUROLOGY; http://hdl.handle.net/11380/1073260; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84943249282; http://www.neurology.org/content/85/14/1224 |
| DOI: | 10.1212/WNL.0000000000001996 |
| الاتاحة: | http://hdl.handle.net/11380/1073260 https://doi.org/10.1212/WNL.0000000000001996 http://www.neurology.org/content/85/14/1224 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.6474E30E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1212/WNL.0000000000001996 |
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