Academic Journal
Graphene-based microelectrodes with bidirectional functionality for next-generation retinal electronic interfaces
| العنوان: | Graphene-based microelectrodes with bidirectional functionality for next-generation retinal electronic interfaces |
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| المؤلفون: | Duvan, F. Taygun, Cunquero, Marina, Masvidal Codina, Eduard, Walston, Steven T., Marsal, María, Cruz, Jose Manuel de la, Viana, Damià, Nguyen, Diep, Degardin, Julie, Illa, Xavi, Zhang, Julie M., Bernicola, María del Pilar, Macías-Montero, José Gabriel, Puigdengoles, Carles, Castro-Olvera, Gustavo, Del Corro, Elena, Dokos, Socrates, Chmeissani, Mokhtar, Loza-Álvarez, Pablo, Picaud, Serge, Garrido, Jose A. |
| المساهمون: | Fundación la Caixa, European Commission, Agence Nationale de la Recherche (France), Generalitat de Catalunya, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Sorbonne Université, Instituto de Salud Carlos III |
| بيانات النشر: | Royal Society of Chemistry (UK) |
| سنة النشر: | 2024 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| الوصف: | This article is part of the themed collection: Graphene and 2D Materials in Healthcare. ; Neuroelectronic prostheses are being developed for restoring vision at the retinal level in patients who have lost their sight due to photoreceptor loss. The core component of these devices is the electrode array, which enables interfacing with retinal neurons. Generating the perception of meaningful images requires high-density microelectrode arrays (MEAs) capable of precisely activating targeted retinal neurons. Achieving this precision necessitates the downscaling of electrodes to micrometer dimensions. However, miniaturization increases electrode impedance, which poses challenges by limiting the amount of current that can be delivered, thereby impairing the electrode's capability for effective neural modulation. Additionally, it elevates noise levels, reducing the signal quality of the recorded neural activity. This report focuses on evaluating reduced graphene oxide (rGO) based devices for interfacing with the retina, showcasing their potential in vision restoration. Our findings reveal low impedance and high charge injection limit for microscale rGO electrodes, confirming their suitability for developing next-generation high-density retinal devices. We successfully demonstrated bidirectional interfacing with cell cultures and explanted retinal tissue, enabling the identification and modulation of multiple cells' activity. Additionally, calcium imaging allowed real-time monitoring of retinal cell dynamics, demonstrating a significant reduction in activated areas with small-sized electrodes. Overall, this study lays the groundwork for developing advanced rGO-based MEAs for high-acuity visual prostheses. ; The project leading to these results have received funding from “la Caixa” Foundation (ID 100010434), under the agreement LCF/PR/HR19/52160003 (i-VISION), European Unions Horizon 2020 research and innovation programme under grant agreement no. 881603 (Graphene flagship Core3), and French state funds managed by the ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/EC/H2020/881603; info:eu-repo/grantAgreement/AEI//FJC2021-046601-I; info:eu-repo/grantAgreement/AEI//RYC2019-027879-I; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113663RB-I00/ES/TECNOLOGIAS NEURALES BASADAS EN MATERIALES 2D/; info:eu-repo/grantAgreement/AEI//SEV-2017-0706; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001214-S; info:eu-repo/grantAgreement/EC/H2020/861423; The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1039/d4nh00282b; https://doi.org/10.1039/d4nh00282b; Sí; http://hdl.handle.net/10261/375789 |
| DOI: | 10.1039/d4nh00282b |
| الاتاحة: | http://hdl.handle.net/10261/375789 https://doi.org/10.1039/d4nh00282b |
| Rights: | open |
| رقم الانضمام: | edsbas.6458C67B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1039/d4nh00282b |
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